子宫颈扩张双球囊与欣普贝生在足月妊娠引产中的临床对照研究  

A Control Study of the COOK Balloon Catheter and Prostaglandin E2 Suppositories in Induction of Labor at Term

作　　者：聂晓露[1] 谭剑平[1] 陈欣[1] 陈慧[1] 张建平[1] 

机构地区：[1]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《热带医学杂志》2013年第2期165-167,共3页Journal of Tropical Medicine

基　　金：国家自然基金(81270754;81170625);广东省科技计划项目(2010B060900034);广东省医学科学技术研究基金(A2010171)

摘　　要：目的探讨COOK促宫颈成熟球囊与前列腺素E2栓剂-欣普贝生在足月引产中应用的有效性和安全性。方法选取2010年3月至2011年8月在本院行引产的孕妇共77例,将其随机分为COOK球囊组(38例)和前列腺素E2栓剂-欣普贝生组(39例),观察两组孕妇宫颈Bishop评分、宫缩情况、临产时间、分娩方式和时间及孕产妇、围产儿的一般状况。结果 COOK球囊组产妇放置后宫颈Bishop评分较放置前有提高,且差异有统计学意义(P<0.05)。COOK球囊组从放置到分娩的时间较欣普贝生组长,但差异无统计学意义(P>0.05),两组剖宫产率差异无统计学意义(P>0.05)。欣普贝生组胎心异常8例(20.51%),球囊组胎心异常2例(5.26%),两组差异有统计学意义(P<0.05)。结论 COOK促宫颈成熟球囊的引产效果与欣普贝生相似,但具有温和、安全、并发症少等优点。Objective To compare the effectiveness and safety of COOK balloon catheter and prostaglandin E2 suppositories in induction of labor at term. Methods 77 pregnant women were divided into two groups, namely the COOK balloon catheter group （38） and prostaglandin E2 suppositories group （39）, between May 2010 and August 2011. The improvement of cervical conditions was compared before and after the application. Uterine contraction, in labor time, fetus delivery method and time, situation of maternal and newborn health were determined. Results The COOK balloon catheter method could effectively increase the cervical Bishop score（P〈0.05）. Compared with the prostaglandin E2 group, the time course from application to delivery in the COOK group was prolonged,but the result was not significant （P〉0.05）. The cesarean section ratio in the COOK group was not different from the prostaglandin E2 group.There were 8 cases （20.51%）with abnormal fetal heart rate in the prostaglandin E2 group and 2 cases （5.26%）in the COOK group. Conclusion Although the efficacy of COOK balloon catheter method is the same as prostaglandin E2 in induced labor at term, it has the advantage of being safe and has less side effect.

关 键 词：欣普贝生 COOK促宫颈成熟球囊 足月引产 

分 类 号：R719[医药卫生—妇产科学]