家兔对乙酰氨基酚口服给药的药代动力学研究  

Pharmacokinetics of Paracetamol Oral Administration in Rabbits

作　　者：杨朝令[1] 李仲娟[1] 石金舟[1] 汪宏良[1] 向环英 

机构地区：[1]湖北理工学院医学院,湖北黄石435003 [2]黄石市临检中心,湖北黄石435003

出　　处：《热带医学杂志》2013年第2期196-198,共3页Journal of Tropical Medicine

基　　金：湖北理工学院创新团队项目(201025);药学省级重点实验室人才引进项目(RCYJ20113012)

摘　　要：目的通过比较对乙酰氨基酚标准品与片剂在家兔体内的吸收曲线,探讨口服给药后对乙酰氨基酚在家兔体内的药物动力学特征。方法比色法测出对乙酰氨基酚的血药浓度,采用3P87软件计算对乙酰氨基酚的药物动力学参数。结果对乙酰氨基酚标准品的标准曲线R2=0.9914;口服药片对乙酰氨基酚15min达峰。药物动力学参数为C0(93.6±1.56)mg/L,V(2.72±0.32)h,t1/2(3.62±0.33)h,AUC(490.7±134.6)mg/h/L,与标准品比较差异无统计学意义。结论片剂对乙酰氨基酚口服给药吸收迅速,在家兔体内符合单室模型动力学特性。Objective To compare the absorption curve after oral administration of Paracetamol in pure powder and tablets in rabbits, and discuss the characteristics of Paracetamol pharmacokinetics. Methods Plasma concentration of Paracetamol in rabbits was determined by colorimetry method. The main pharmacokinetic parameters of Paracetamol were analyzed by 3p87 software. Results The standard curves （R2=0.9914） and absorption curves of pills solution and the pure powder of Paracetamol were the same.The absorption peak appeared in 15min, but the tablet was significantly lower than the pure powder.The main pharmacokinetic parameters of Paracetamol were as follows Co （93.6±l.56）mg/L,V （2.72±0.32）h, tl/z（3.62±O.33）h and AUC（490.7±134.6） mg/h/L. Conclusion Oral administration of Paracetamol is rapidly absorbed in the body in line with single-compartment model dynamics.

关 键 词：吸收曲线 对乙酰氨基酚 比色法 单室模型 

分 类 号：R969.1[医药卫生—药理学]