淋巴细胞主动免疫治疗不明原因复发性流产的临床研究  

Clinical Study of Active Immunotherapy in the Treatment of Unexplained Recurrent Spontaneous Abortion

作　　者：袁晓兰[1] 张温麑[1] 麦明琴[1] 吴菁[1] 黄华梅[1] 

机构地区：[1]广东省妇幼保健院妇产科产前诊断中心,广东广州510010

出　　处：《热带医学杂志》2013年第2期212-214,共3页Journal of Tropical Medicine

基　　金：广州市科技计划项目(2010Y1-C261)

摘　　要：目的研究不明原因复发性流产患者免疫治疗前后的封闭抗体(BA)变化及其妊娠结局。方法封闭抗体阴性的复发性流产患者采用丈夫外周血淋巴细胞主动免疫治疗,比较治疗前后封闭抗体变化,并比较接受免疫治疗与未接受治疗的妊娠成功的患者的妊娠结局。结果主动免疫治疗后封闭抗体阳性率为72.91%;接受免疫治疗者妊娠成功率为68.86%,BA阴性未接受免疫治疗者妊娠成功率为27.13%,差异有统计学意义;免疫治疗后封闭抗体阳性者妊娠成功率达82.95%,免疫治疗后BA阴性者妊娠成功率为34.93%,差异有统计学意义;两组患者病理妊娠结局、新生儿畸形率差异无统计学意义。结论封闭抗体缺乏是不明原因复发性流产的一个重要原因,淋巴细胞主动免疫治疗是比较有效的治疗手段。Objective To compare the blocking antibodies before and after immunotherapy in the patients with unexplained recurrent spontaneous abortion and analyze their pregnancy outcomes. Methods Active immunotherapy with lymphocytes of husband was conducted in the patients with unexplained recurrent spontaneous abortion who were tested negative for blocking antibodies. The blocking antibodies before immunotherapy were compared to those after immunotherapy, and the pregnancy outcomes of patients accepting immunotherapy were compared to those refusing immunotherapy. Results After immunotherapy,the positive rate of blocking antibodies was 72.91% ,and successful pregnancy rate was 68.86% , however, the successful pregnancy rate in those negative for blocking antibodies and refusing immunotherapy was 27.13%, showing a statistical significant difference.Blocking antibody positive successful pregnancy rate was 82.95% after immunotherapy, however,blocking antibody negative successful pregnancy rate was 34.93%, showing a statistical significant difference. There was no significant difference in pathological pregnancy outcomes and birth defect rate between two groups. Conclusion Deficiency of blocking antibodies is one of the main reasons for unexplained recurrent spontaneous abortion, and active immunotherapy is the effective treatment for those negative for blocking antibodies.

关 键 词：不明原因复发性流产 免疫治疗 封闭抗体 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]