术连饮治疗功能性消化不良的实验研究  

Study on Zhulian Yin for treating functional dyspepsia

作　　者：刘蔚雯[1] 吴香新[2] 

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建医科大学实验动物中心,福建福州350122

出　　处：《中国医药科学》2013年第3期37-38,100,共3页China Medicine And Pharmacy

基　　金：福建省自然科学基金项目(2009J01165)

摘　　要：目的探讨术连饮对功能性消化不良大鼠肠动力的影响及其可能的作用机制。方法将SD大鼠随机分组,每组10只,分别为正常组、模型组、术连饮组和西沙比利组。制作功能性消化不良大鼠动物模型,以葡聚糖蓝-2000为胃肠内标记物,观察大鼠肠道传输速率的变化。测定大鼠血浆及十二指肠组织胃动素、生长抑素的水平。结果模型组大鼠肠道传输速率明显降低(P<0.05),血浆及十二指肠组织MOT含量明显降低(P<0.01)、SST含量明显升高(P<0.01)。术连饮能够显著促进模型大鼠肠道传输速率(P<0.05),显著增加血浆及十二指肠组织MOT含量(P<0.05),降低SST水平(P<0.05)。结论术连饮能够改善FD大鼠肠运动障碍,其作用机制可能通过提高血浆及十二指肠组织MOT,降低SST,以促进肠动力。Objective To investigate the effect of Zhulian Yin on intestinal motility in rats with functional dyspepsia and its mechanism. Methods SD rats were randomized into normal group model group, Zhulian Yin group and eisapride group, 10 rats in each one. Gastroelectric dysrhythmias model was duplicated in rats. After drug intervention, dextran blue-2000 was used as gastrointestinal marker to observe the changes of gastrointestinal transit rate. Changes in motilin, somatostatin contents in peripheral blood and distributions of duodenal were determined. Results Compared with the normal control group, the gastrointestinal transit rate reduced significantly in rats （P 〈 0.05）. The plasma MOT in peripheral blood and distributions of duodenal were decreased significantly and the SST level elevated significantly （P 〈 0.01）. Zhulian Yin promoted the gastrointestinal transit rate apparently in modeled rats（P 〈 0.05）, the plasma MOT in peripheral blood and distributions of duodenal were significantly higher and the SST level significantly lower（P 〈 0.05）. ConclusionZhulian Yin can improve intestinal motility of rats with functional dyspepsia, which may be related to the increased the plasma MOT in peripheral blood and distributions of duodenal and reduced the SST level.

关 键 词：术连饮 功能性消化不良 胃动素 生长抑素 

分 类 号：R259[医药卫生—中西医结合]