乙型肝炎病毒慢性感染基础对散发性戊型肝炎临床特点的影响  

Effect of Basis on Chronic Infection of Hepatitis B Virus on Clinical Fectures of Sporadic Hepatitis E

作　　者：肖湘明[1] 曹红[2] 邓洪[2] 黄仰甦 柯伟民[2] 

机构地区：[1]广东省汕头市中心医院传染科,汕头515031 [2]广东省中山医科大学第三附属医院传染病学教研室

出　　处：《实用预防医学》2000年第4期247-249,共3页Practical Preventive Medicine

摘　　要：[目的 ]　阐明乙型肝炎病毒慢性感染基础对散发性戊型肝炎临床表现、肝功能指标、血清学规律和预后的影响。 [方法 ]　比较分析 10 0例慢性乙型肝炎重叠散发性戊型肝炎患者和 144例散发性戊型肝炎患者的发病年龄、住院时间 ;血清丙氨酸转氨酶 (ALT)、总胆红素 (TB)、谷氨酰转肽酶 (GGT )、碱性磷酸酶 (AKP)和凝血酶原时间(PT)的水平 ;不同病周的抗 -HEV -IgM、抗 -HEV -IgG的阳性率 ;以及病死率。[结果 ]　慢性乙型肝炎重叠散发性戊型肝炎组患者的发病年龄、1～ 2、3～ 4病周的抗 -HEVIgG和 5～ 2 6病周的抗 -HEVIgM、IgG阳性率均明显低于散发性戊型肝炎组 ,而住院时间 ,TB、GGT、AKP和PT水平和病死率明显高于散发性戊型肝炎组患者 (P <0 0 5～0 0 1)。 [结论 ]　乙型肝炎病毒的慢性感染基础使散发性戊型肝炎患者的发病年龄降低、住院时间延长、肝内瘀胆明显、病情加重和预后变差 ;而且 ,缩短抗 -HEV -IgM在恢复期的持续时间和降低抗 -HEVObjective] To clarify effect of basis on chronic infection of hepatatis B virus on clinical manifestations, indexes of liver function, regulations of serology and prognosis of sporadic hepatitis E.[Methods] Attack age、 hospitalized course、serumal alanine aminotransferase (ALT)、 totoal bilirubin(TB)、prothrombin time(PT), glutamyl transpetidase(GGT), alkaline phosphatase(ALP), anti-HEV-IgM in the different weeks after onset and mortality rate were compared in 100 cases with chronic hepatitis B superinfected with sporadic hepatitis E and 144 cases of sporadic hepatitis E.[Result] there were differences in attack age, hospitalized course, ALT, TB, PT, GGT, ALP, anti-HEV-IgM in 5～26 weeks after onset, anti-HEV-IgG in 1～2,3～4,5～26 weeks after onset and mortality rate between the groups of chroic hepatitis B superinfected with sporadic hepatitis E and groups of sporadic hepatitis E (P<0 05～0 01)。[Conclusion] The basics of chronic infection of hepatitis B causes declined attack age, prolonged hospitalized course, changed prominently in cholestasis, aggravated in patient's condition and poor prognosis, as well as shortened the persistent time of anti-HEV-IgM in the convalescent period and declined the seroconversion of anti-HEV-IgG in the sporadic hepatitis E.

关 键 词：散发性戊型肝炎 乙型肝炎 临床疾病特点 

分 类 号：R512.62[医药卫生—内科学]