斑点追踪技术对研究心肌再灌注损伤的应用价值  

Value of speckle tracking imaging for research on myocardial reperfusion injury

作　　者：宋平梅[1] 任卫东[1] 乔伟[1] 王秀芹[1] 张光华[1] 

机构地区：[1]中国医科大学附属盛京医院超声科,辽宁沈阳110004

出　　处：《中国临床医学影像杂志》2013年第3期166-168,173,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:应用斑点追踪技术研究再灌注损伤对心肌收缩功能的影响。方法:将20只健康成年杂种犬左冠状动脉第一对角支下方结扎180 min并再灌注120 min,分别对结扎前、结扎即刻、结扎180 min及再灌注即刻、60 min和120 min基底水平、乳头肌水平和心尖水平心肌的圆周应变进行比较。结果:基底水平心肌再灌注即刻圆周应变下降,再灌注后上升,高于基础状态。乳头肌水平心肌再灌注后圆周应变上升,仍低于基础状态,没有显著性差异。心尖水平心肌再灌注后上升,低于基础状态且有显著性差异。结论:斑点追踪技术能够客观准确的评价再灌注损伤对心肌收缩功能的影响,为尽早解除冠脉梗阻状态及治疗方案的选择提供有效的参考指标。Objective： To explore the impact of reperfusion injury on myocardial systolic function by speckle tracking imaging. Methods： Left anterior descending （LAD） coronary of 20 healthy adult hybrid dogs were ligated for 180 minutes following by reperfusion for 120 minutes. Circumferential strain of basal, papillary muscle and apical level were compared by speckle tracking imaging before LAD occlusion, LAD occlusion immediately, LAD occlusion for 180 minutes, reperfusion immediately, reperfusion for 60 and 120 minutes respectively. Results： Circumferential strain of basal level decreased after reperfusion and then increased above the basic status. Circumferential strain of papillary muscle level increased after reperfusion, but it was still lower than that of the basic status without significant difference. Circumferential strain of apical level increased and it was lower than that of the basic status with significant difference. Conclusion： Speckle tracking imaging can assess the influcence of reperfusion injury on myocardial contractility objectivly and accurately, which will provide an effective index for relieving the coronary obstruction early and choose proper treatment.

关 键 词：心肌再灌注损伤 超声心动描记术 狗 

分 类 号：R541.4[医药卫生—心血管疾病] R540.45[医药卫生—内科学]