5-羟色胺转运体基因启动子区基因多态性与原发性早泄遗传关联性Meta分析  

Association of 5-HTTLPR polymorphisms with primary premature ejaculation: A meta-analysis

作　　者：夏佳东[1] 周六化[1] 陈赟[1] 朱伟东[1] 戴玉田[1] 

机构地区：[1]南京医科大学鼓楼临床医学院男科,南京医学博士210008

出　　处：《医学研究生学报》2013年第3期260-264,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81170563)

摘　　要：目的原发性早泄是男性常见的性功能障碍疾病。目前,5-羟色胺转运体基因启动子区(serotonin transporterpromoter,5-HTTLPR)的基因多态性与原发性早泄的关联性研究结果不尽一致。文中旨在系统评价5-HTTLPR多态性与原发性早泄的遗传关联性。方法电子检索PubMed、Embase、Cochrane、中国期刊全文数据库、维普中文科技期刊库和万方数据库,筛选和纳入5-HTTLPR基因多态性与原发性早泄关联性的病例对照研究,依据相关文献选择5条标准用于评价文献质量。以基因型频率为指标,提取数据后先确定最佳遗传模型,采用Stata 11.0软件进行Meta分析,计算合并的OR值及95%CI。结果 5篇病例对照研究进入Meta分析,病例组449例,对照组434例。采用共显性模型进行Meta分析,结果显示SS基因型较LL基因型者原发性早泄的风险增加(OR=1.65,95%CI:1.15～2.36,P=0.007);对不同人群进行亚组分析提示亚洲人群SS基因型较LL基因型(OR=2.12,95%CI:1.26～3.58,P=0.005)和SL基因型(OR=1.69,95%CI:1.03～2.77,P=0.040)患原发性早泄的风险显著增加;欧洲人群5-HTTLPR基因与原发性早泄无显著关联性(SS基因型vs LL基因型,OR=1.31,95%CI:0.79～2.16,P=0.292;SS基因型vs SL基因型,OR=1.42,95%CI:0.60～3.34,P=0.423)。结论亚洲人群5-HTTLPR位点SS基因型为原发性早泄的危险因素,而在欧洲人群其多态性与原发性早泄的关联性尚不明确。Objective Primary premature ejaculation （PPE） is a common male sexual dysfunction disease. The results of several studies are contradictory on the association between polymorphisms of serotonin transporter promoter gene （5-HTYLPR） and PPE. This meta-analysis is to evaluate their association. Methods We searched PubMed, Embase, Cochrane, China National Knowledge Infrastructure, VIP Chinese Periodical Database and Wanfang Chinese Periodical Database for the case-control studies about the association of 5-HTrLPR gene polymorphisms with PPE, and evaluated the included studies for bias by five standards based on the relevant literature. We selected the best genetic model, performed meta-analysis of all the eligible studies using Stata 11.0 software, investigated the heterogeneity among individual studies and calculated the pooled odds ratio （OR） and 95% confidence interval （CI）. Results A total of 5 eligible studies were included, with 449 cases and 434 healthy controls. Analysis with the codominant genetic model indicated a higher risk of PPE in those with the SS genotype than in those with the LL genotype （OR = 1.65, 95% CI： 1.15 -2.36, P = 0. 007 ）. Subgroup analyses showed that 5-HTYLPR was significantly associated with PPE in the Asian population （ SS vs LL： OR=2.12, 95% CI： 1.26-3.58, P=0.005; SS vs SL： OR= 1.69, 95% CI： 1.03 -2.77, P=0.040）, but not in the European population （OR =1.31, 95% CI： 0.79 - 2.16, P = 0. 292; SS vsSL： OR = 1.42, 95% CI ： 0.60 - 3.34, P = 0.423）. Conclusion The SS genotype is a risk factor of PPE in the Asian population, but the association of 5-HTTLPR polymorphisms with PPE is not yet confirmed in the European population.

关 键 词：原发性早泄 5-羟色胺转运体 基因多态性 META分析 

分 类 号：R698[医药卫生—泌尿科学]