红花黄色素对不稳定性心绞痛患者Th1/2细胞漂移的干预作用  

Intervention effect of Safflower Yellow injection on Th1/2 cell drift in patients with unstable angina pectoris

作　　者：朱哲蓓 姜红菊[2] 宋伟兴[2] 周苏宁[3] 

机构地区：[1]宁波明州医院心血管内科,浙江宁波315010 [2]山东中医药大学第二附属医院心血管内科,济南250001 [3]山东省立医院心血管内科,济南250021

出　　处：《中国临床药理学杂志》2013年第3期166-168,179,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察红花黄色素注射液对不稳定心绞痛患者的疗效及对外周血Th1/Th2细胞漂移的影响。方法 60例不稳定型心绞痛患者随机分为2组,对照组进行常规西药治疗;在常规治疗基础上,治疗组静滴红花黄色素150 mg,每日1次,疗程10天。观察治疗前后的主要临床症状、中医症候的变化;用酶联免疫吸附法检测外周血的γ干扰素(INF-γ)、白介素-2(IL-2)、白介素-4(IL-4)、白介素-10(IL-10)的变化。结果对心绞痛疗效与中医症状积分:治疗前后比较2组差异均有统计学意义(P<0.05);2组间治疗后比较差异有统计学意义(P<0.05)。治疗前,外周血中的INF-γ、IL-2、IL-4、IL-10水平,2组差异均无统计学意义(P>0.05)。治疗后,2组的IFN-γ、IL-2水平均明显下降(P<0.05);2组间比较差异也具有统计学意义(P<0.05)。结论红花黄色素注射液能够有效改善心绞痛患者的症状,对Th1/Th2细胞漂移的作用可能是机制之一。Objective To investigate the effects of Safflower Yellow injection on the unstable angina pectoris and levels of Th1/Th2 cell drift in the patients plasma.Methods Divided 60 patients with unstable angina pectoris into 2 groups,including control group and trial group.The trial group was treated with Safflower Yellow injection（150 mg,onece daily,10 days of the duration）combined with conventional western medicine,and control group was treated with conventional western medicine only.The clinical symptom and traditional Chinese medicine（TCM）symptoms were observed in all cases.The serum interferon-γ（INF-γ）,interleukin-4（IL-4）,IL-2,IL-10 levels were determined with enzyme association immunity adsorption law.Results After treatment,the effect of clinical improvement of syndromes in trial group was better than those in control group（P0.05）.There is significant difference between the two groups（P0.05） on the TCM symptomatic scores.The plasma levels of INF-γ,IL-4,IL-2,IL-10 in two groups were not significantly different.The level of IFN-γ,IL-2 after treatment in both groups were lower than those before treatment,and the level of those in the trial group were significantly lower than those in control（all P0.05）.Conclusion Safflower Yellow injection can obviously improve the clinical symptoms of the unstable angina patients.The effect of Safflower Yellow injection on the improvement of Th1/Th2 cell drift may be one of the function mechanism.

关 键 词：红花黄色素注射液 不稳定性心绞痛 TH1 Th2细胞漂移 

分 类 号：R285.6[医药卫生—中药学] R541.4[医药卫生—中医学]