艾滋病病毒感染者和艾滋病患者神经认知功能的初步研究  

A preliminary study of neurocognitive function of HIV ＋/AIDS patients

作　　者：赵婷婷[1] 黄建荣 唐咸艳[1] 韦波[1] 

机构地区：[1]广西医科大学公共卫生学院流行病学教研室,南宁530022 [2]广西民族医院神经科

出　　处：《中华行为医学与脑科学杂志》2013年第2期147-149,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：广西卫生厅重点课题（桂卫重2011087）

摘　　要：目的探讨艾滋病病毒感染者（HIV＋）和艾滋病患者（AIDS）的神经认知功能变化，了解艾滋病病毒感染者和艾滋病患者中各神经心理测试条目的异常发生数和比例，并分析神经心理测试结果与HAND临床诊断结果的相关性。方法运用全套神经心理测验对通过多阶段分层随机抽取到的230例HIV＋／AIDS住院病人和99例HIV阴性者进行神经认知功能研究。结果HIV／AIDS患者中12项神经心理测试条目异常发生比例不等，位于21．3％～58．7％之间。12项神经心理测评结果都与HAND临床诊断结果存在相关关系，其中SC时间、SCW时间、颜色连线和WSCT持续错误数4个条目测评结果与临床诊断结果成正相关，相关系数分别为0．384，0．335，0．237和0．129。其余测试项目的测评结果与临床诊断结果成负相关，相关系数最高的是词汇流畅性，最低的是WSCT持续错误数。结论HIV／AIDS患者中12项神经心理测试条目的异常发生比例较高，且均影响着受试者有无HIV相关性神经认知障碍的评定。提示全套神经心理测验可较好的用于HIV／AIDS患者神经认知功能的初步研究。Objective To examine cognitive function of the HIV/AIDS patients in the hospitals measured by the neuropsychological tests battery, make an evaluation of cognitive function of the HIV/AIDS patients, and di-agnose the patients with HIV-associated neurocognitive disorders （HAND）. Methods Ninety-nine normal individ-uals and two hundred and thirty HIV/AIDS inpatients ,who were sampled by multi-stage random stratified in Guan-gxi,were tested by the 12 items of the neuropsychological tests. Results HIV / AIDS patients with abnormal neu-ropsychological test entries proportion ranges located between 21.3%-58.7 %. The results of 12 items of the neu-ropsyehological tests were associated with the results of clinical diagnosis. Among them, the results of SC time, SCW time, color attachment, and numbers of the contiguous error in WSCT tests were positively associated with the results of clinical diagnosis, and the correlation coefficient were 0. 384,0. 335,0. 237 and 0. 129, respectively. There was a negative correlation between the results of the rest assessment and the results of clinical diagnosis ; vo-cabulary fluency was the highest correlation coefficient, while numbers of the contiguous error in WSCT tests was the lowest. Conclusion A higher proportion of abnormal occurrence of Guangxi HIV / AIDS patients in the 12 neuropsychological test entry, and affect the subjects with or without HIV-related neurological assessment of cogni-tive impairment. The data suggest that a full neuropsychological tests can be better used for the preliminary study of the HIV ＋/AIDS patients neurocognitive function.

关 键 词：HIV AIDS HIV相关性神经认知障碍 神经心理测验 

分 类 号：R51[医药卫生—内科学]