基于天然产物骨架的有机凝胶  

Organogels Based on Natural Products

作　　者：卢金荣[1] 巨勇[1,2] 

机构地区：[1]清华大学化学系生命有机磷化学及化学生物学教育部重点实验室,北京100084 [2]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《有机化学》2013年第3期469-482,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21172130);国家重点基础研究发展规划(973计划)(No.2012CB821600)资助项目~~

摘　　要：天然产物结构复杂,生理活性独特,常被用作先导化合物,经过结构修饰和改造,发展为具有重要药用价值的化合物,在保障人类健康方面发挥重要的作用.近年来,具有独特立体结构、多修饰位点、良好生物相容性和生物活性的天然产物作为构筑单元,已应用到基于分子自组装的有机功能材料研究领域中.介绍以天然甾体、三萜、肽、糖等为结构骨架,设计合成的功能分子在有机凝胶方面的研究现状及其潜在的应用.Due to diverse structures and distinctive biological activities, natural products have important physiological functions and they are usually used to be therapeutic drugs and good lead compounds after structural modification and transformation. Because of chiral rigid skeleton, multiple reaction sites and biocompatibility, natural products are also as building blocks in supraaaolecular self-assembly. this review, the recent development of organogels based on natural products, such as ster- oids, triterpenoid, pcptides, carbohydrates and so on are briefly summarized.

关 键 词：天然产物 有机凝胶 甾体 三萜 肽 糖 

分 类 号：O648.17[理学—物理化学]