5-氨基酮戊酸盐酸盐的合成新方法  

A Novel Synthetic Method of 5-Aminolevulinic Acid Hydrochloride

作　　者：迟鹏利[1] 谢崔越[1] 林吉茂[1] 

机构地区：[1]山东大学化学与化工学院,济南250100

出　　处：《有机化学》2013年第3期640-642,共3页Chinese Journal of Organic Chemistry

摘　　要：研究了5-氨基酮戊酸(5-ALA)盐酸盐的合成新方法,以相对廉价易得的环氧氯丙烷为起始原料,通过盖布瑞尔反应、开环、氧化、取代、水解等反应步骤得到目标产物5-氨基酮戊酸盐酸盐.研究表明该方法具有原料便宜易得、总收率高、产物易分离纯化、后处理操作简单、总成本低等优点.In this paper, a novel synthetic method of 5-aminolevulinic acid （5-ALA） hydrochloride was described starting from cheap and easily available epichlorohydrin. The 5-aminolevulinic acid hydrochloride was obtained by Gabriel reaction, ring-opening, oxidation, substitution and hydrolysis. The results showed that the synthetic method has the advantages of mate- rials being simply available, good overall yield, easily work-up and low cost.

关 键 词：环氧氯丙烷 5-氨基酮戊酸盐酸盐 合成 

分 类 号：TQ463[化学工程—制药化工]