HPLC法测定优吗多中微量顺式异构体的含量  

Study on the Determination of Cis-isomer of Tramadol by HPLC

作　　者：张菁[1] 李俊德[2] 杨亚青[2] 

机构地区：[1]河北省药品检验所,石家庄050051 [2]石家庄制药集团

出　　处：《中国药事》2000年第4期245-246,共2页Chinese Pharmaceutical Affairs

摘　　要：采用高效液相色谱法测定优吗多中顺式异构体的含量。色谱条件为 :Shim -packCLC -ODS柱 ,甲醇 -乙酸钠缓冲液 (50∶50 )为流动相 ,流速 :1 0ml min ,检测波长 2 71nm ,方法的精密度、线性关系和回收率均良好 ,本法方便、快捷。A HPLC method for content determination of cis-isomer of tramadol were established. The column is Shim-pack CLC-ODS. The mobile phase is methanol-sodium acetate buffer (50∶50) and the flow rare is 1.0ml/min. The detection wavelength is 271nm. The method has good precision, linear range, and recovery.

关 键 词：优吗多 微量顺式异构体 高效液相色谱法 

分 类 号：R971.2[医药卫生—药品]