山栀茶水提物和醇提物的抗抑郁作用研究  

Antidepression Effect of the Aqueous and Ethanol Extracts of Radix Pittospori

作　　者：左晓娜[1,2] 肖炳坤[1] 刘妍如[3] 杨建云[1] 甄蓓[1] 黄荣清[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]江西中医学院,江西南昌330006 [3]沈阳药科大学,辽宁沈阳110016

出　　处：《时珍国医国药》2013年第3期530-531,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81072613);十二五国家科技重大专项"重大新药创制"综合性新药研究开发技术大平台(No.2012ZX09301003-001-010)

摘　　要：目的以药效学方法研究山栀茶的抗抑郁作用。方法连续21天给予小鼠一系列慢性不可预见性刺激,建立慢性应激模型,同时采用小鼠强迫游泳实验和小鼠悬尾实验作为山栀茶不同溶剂提取物抗抑郁活性的评价指标。结果与模型组比较,山栀茶的水提物和醇提物的高、低剂量组均能不同程度地缩短小鼠强迫游泳和小鼠悬尾实验的不动时间,具有统计学意义。结论山栀茶水提物和醇提物具有一定的抗抑郁作用。Objective To screen the antidepressant-like effect of Radix Pittospori by pharmacodynamic method.Methods Making a chronic mild stress（CMS） model during 3 weeks,and the forced swimming and the tail suspending test were used to evaluate the antidepressant-like effect of the aqueous and ethanol extracts of Radix Pittospori.Results Compared to CMS group,the aqueous and ethanol extracts of Radix Pittospori can significantly shorted immobility time of mice in the forced swimming and the tail suspending test.Conclusion The aqueous and ethanol extracts of Radix Pittospori sugguest a significant antidepressant-like effect.

关 键 词：山栀茶 抗抑郁 强迫游泳实验 悬挂尾实验 

分 类 号：R285.5[医药卫生—中药学]