虚寒性出血证大鼠模型的研究  

Study on the deficiency-cold and bleed mouse model

作　　者：杜晶[1] 孟江[1] 梁慧超[1] 朱琼华[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《时珍国医国药》2013年第3期754-756,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81102809)

摘　　要：目的比较几种虚寒性出血证动物的造模方法,寻找适宜的虚寒性出血证动物模型。方法采用大黄、龙胆草、中药复方、大黄联合利血平及苦降泻下、饮食失节加劳倦过度法造模分别给药造成虚寒模型,再结合放血法造成虚寒性出血证动物模型。结果采用大黄利血平加放血造模法,虚寒体征明显,血常规四项具有显著性差异。结论该方法操作简便,周期较短,症状明显,适合用于虚寒性出血证动物模型。Objective To compare the different methods of deficiency-cold and bleed mouse model and to find a better mouse model with deficiency-cold and bleed sign.Methods Deficiency-cold modle was established by the different bitter cold drug,such as Rhubarb,Gentian,Chinese compound formula,and reserpine.Bleeding model was established by bloodletting method.Results The mouse model of Rhubarb reserpine and bloodletting method had Significant deficiency-cold sign.Blood tests had significant difference.Conclusion This method was easy to operate and the cycle was short.It was suitable for deficiency-cold and bleed mouse model.

关 键 词：虚寒性出血证 大鼠模型 

分 类 号：R203[医药卫生—中医学]