颗粒蛋白前体与糖尿病及肥胖的关系  

Relationship of progranulin with diabetes mellitus and obesity

作　　者：瞿华[1] 邓华聪[1] 胡振平[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《国际内分泌代谢杂志》2013年第2期104-106,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81070639,30771038）

摘　　要：颗粒蛋白前体是一种分泌性蛋白，广泛表达于各种组织，尤其是快速增殖的细胞中，参与胚胎发育、损伤修复、细胞周期等病理生理过程。炎性反应与2型糖尿病及肥胖相关，并且是胰岛素抵抗形成的重要机制之一。最新研究发现，颗粒蛋白前体在2型糖尿病及肥胖患者的体内表达明显升高，并通过白细胞介素-6炎性反应信号通路参与慢性炎性反应状态及胰岛素抵抗的形成，提示颗粒蛋白前体可能与2型糖尿病及肥胖的发病密切相关。Progranulin is a secreted protein, which is expressed in a wide variety of tissues, especial- ly in highly proliferative cells, participating in the pathophysiologieal processes of embryonic development, wound repair,cell cycle and so on. Chronic inflammation is associated with diabetes and obesity, and it is considered to be one of the most important mechanisms of insulin resistance. Recent studies have found that concentrations of serum progranulin in patients with type 2 diabetes and obesity were high. Beside, progranulin participates in the chronic inflammatory state and insulin resistance through interleukin-6 inflammatory pathway. It indicates that progranulin maybe associate with the pathogenesis of type 2 diabetes and obesity.

关 键 词：颗粒蛋白前体 2型糖尿病 肥胖 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]