5-氨基水杨酸结肠定位渗透泵微丸在大鼠体内释药特性考察  

Investigation of in vivo Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats

作　　者：杨志欣[1] 徐珍[1] 杜素美[1] 常爽[1] 杨波[1] 

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《中国实验方剂学杂志》2013年第7期1-6,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：黑龙江省自然科学基金项目(D200627);黑龙江省教育厅骨干教师资助项目(1251G058);国家教育部春晖计划项目(Z2008-1-15016)

摘　　要：目的:考察基于渗透泵酶触发原理的5-氨基水杨酸(5-ASA)结肠定位微丸的体内释药行为,评价其结肠定位释药特性。方法:将5-ASA结肠定位微丸(微丸组)与5-ASA羧甲基纤维素钠混悬溶液(对照组)分别给大鼠灌胃,于规定时间间隔从大鼠心脏取血,并取出胃、小肠、盲肠、结肠及其内容物,计算相对靶向释药指数(DDI值);扫描电镜观察不同部位的微丸表面结构。结果:微丸组在胃、小肠、盲肠、结肠中的DDI值分别为11.09,12.08,187.25,181.68。扫描电镜观察结肠内微丸有清晰可见的孔径。结论:5-ASA结肠定位微丸具有良好的结肠定位释药性。Objective： To investigate in vivo release behaviour of 5-aminosalicylic acid （5-ASA） colon- specific pellets in rats, which based on osmotic pump enzyme trigger principle, and evaluate its colon localization release characteristics. Method： 5-ASA colon-specific pellets （the pellet group ） with 5-ASA sodium carboxymethyl cellulose suspension （the control group ） were given to rats by intragastric administration respectively, then got blood from rat heart in predetermined time intervals, and removed the stomach, small intestine, cecum, colon and their contents, relative targeted release index （DDI value） of them were calculated; Pellets＇ surface structure of different parts were observed by scanning electron microscope. Result： DDI value of the pellets group in the stomach, small intestine, cecum and colon w^re 11.09, 12.08, 187.25, 181.68, respectively. We could observe that pellets had clearly visible aperture in the colon by scanning electron microscope. Conclusion： 5-ASA colon-specific pellets had good drug release in colon-specific.

关 键 词：5-氨基水杨酸 微丸 结肠定位给药系统 渗透泵酶触发 体内药物释放 

分 类 号：R283.6[医药卫生—中药学]