正交试验优选艾蒿黄酮乳膏基质处方  

Optimization of Matrix Formulation of Artemisia Flavonoids Cream by Orthogonal Test

作　　者：丁洁 王爱霞[2] 牛犇 梁宁 高俊[2] 

机构地区：[1]甘肃省商业科技研究所,兰州730020 [2]甘肃省人民医院,兰州730000

出　　处：《中国实验方剂学杂志》2013年第7期49-52,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：甘肃省科技厅科技开发项目(0805TCYA042)

摘　　要：目的:优选艾蒿黄酮乳膏的基质组成及配比。方法:以乳膏的外观形状、稳定性、延展性、黏度、显微镜观察及pH等为综合评价指标,采用L9(34)正交试验设计对基质中十六醇、十八醇、乳化剂及1,3-丙二醇的用量进行优化。结果:艾蒿黄酮乳膏的最佳基质配比为艾蒿总黄酮0.5%,十六醇6%,十八醇6%,乳化剂8%,1,3-丙二醇4%,尿素2%,纯水64%。结论:按优选工艺制备的艾蒿黄酮乳膏外观细腻均匀,黏度及延展性适宜,性状稳定,颜色呈亮黄色,有中药特殊气味,符合使用要求。Objective： To optimize matrix composition and ratio of artemisia flavonoids cream. Method： L9 （34） orthogonal test was employed to investigate effects of four factors including the amount of cetyl alcohol, octadecanol, emulsifiers, 1, 3-propylene glycol on matrix formulation, with appearance, stability, ductility, viscosity, pH value and microscopic observation as comprehensive evaluation index. Result： The best proportion of matrix prescription was as following： artemisia flavonoids 0.5% , cetyl alcohol 6% , octadecano 6% , emulsifier 8% , 1, 3-propylene glycol 4% , urea 2% , pure water 64%. Conclusion： This prepared cream was fine and uniform with suitable consistence and ductility, stable properties. The color of it was bright yellow, odor was special smell of traditional Chinese medicine, it was in line with the requirements.

关 键 词：艾蒿黄酮 痤疮 乳膏基质 正交试验 工艺配比 

分 类 号：R283.6[医药卫生—中药学]