毛果一枝黄花化学成分研究  

Studies on Chemical Constituents of Solidago virgaurea

作　　者：李涛[1,2] 白虹[1,2] 仲浩[1,2] 邓志鹏[1,2] 姚庆强[1,2] 

机构地区：[1]山东省医学科学院药物研究所 [2]济南大学山东省医学科学院医学与生命科学学院/山东省罕少见病重点实验室,济南250062

出　　处：《中国实验方剂学杂志》2013年第7期140-143,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省泰山学者-药学特聘专家专项建设工程经费资助

摘　　要：目的:对毛果一枝黄花Solidago virgaurea的化学成分进行研究。方法:采用硅胶柱色谱,凝胶柱色谱,ODS反相柱色谱以及重结晶等方法分离纯化,并通过理化常数和波谱分析鉴定化合物结构。结果:分离并鉴定出了12个化合物,分别为2'-甲氧基-2-甲氧基-6-羟基苯甲酸酯(1),2'-甲氧基-2,6-二甲氧基苯甲酸酯(2),β-乙酰香树脂醇乙酸酯(3),α-菠菜甾醇(4),豆甾-7,22-二烯-3-酮(5),2-羟基-6-甲氧基苯甲酸(6),胡麻素(7),槲皮素(8),山奈酚(9),3β-acetoxyolean-12-en-11-one-acetate(10)和N-benzoylphenylalaninyl-N-benzoylphenylalaninate(11),原儿茶酸(12)。结论:化合物11为首次从该科植物中分离得到,化合物5,10为该属内首次分离,化合物1,2,3,6,7,12为首次从该植物中分离得到。Objective： To Study the chemical constituents of the Solidago virgaurea. Method： The compounds were isolated and purified from the plant with chromatography techniques and the structures were identified on the basis of spectral analyses and physicochemical properties. Result： Twelve compounds were isolated from S. virgaurea and their structures were identified as 2＇-methoxybenzyl-2-methoxy-6-hydroxybenzoate, 2＇-methoxybenzyl-2, 6-dimetho-xybenzoate, β-amyrin acetate, a-spinasterol, stigmasta-7, 22-dien-3-one, hexadecanoic acid, 2-hydroxy-6-methoxybenzoic acid, pedalitin, quercecetin, kaemferol, 3β-acetoxyolean-12-en- ll-one-acetate, N-benzoylphenylalaninyl-N-benzoylphenylalaninate and protocatechoic acid. Conclusion： Compounds 11 was isolated from Solidago for the first time, compounds 5 and 10 were isolated from Solidago genus for the first time, compounds 1, 2, 3, 6, 7 and 12 were isolated from the plant for the first time.

关 键 词：毛果一枝黄花 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]