降脂保肝方对糖尿病高脂血症大鼠糖脂代谢紊乱的影响  

Effects of Jiangzhi Baoganfang on the Metabolic Disorders of Glucose and Lipid in Type 2 Diabetic Rat with Hyperlipemia

作　　者：杨蕙 王宇红[1,2] 莫韦皓[2] 

机构地区：[1]湖南省中药粉体与创新药物省部共建国家重点实验室培育基地,长沙410007 [2]湖南中医药大学第一附属医院中药药理(心血管)实验室,长沙410007

出　　处：《中国实验方剂学杂志》2013年第7期230-233,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨降脂保肝方对糖尿病高脂血症大鼠糖脂代谢紊乱的影响。方法:采用高脂乳剂灌胃联合尾静脉注射链脲佐菌素(STZ,38 mg.kg-1)制备大鼠2型糖尿病模型,随机分为模型组、阳性药(二甲双胍0.18 g.kg-1)组、降脂保肝方组9.54 g.kg-1并设正常对照组,ig连续给药35 d。实验结束后,测定各组大鼠空腹血糖(FPG),糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、丙二醛(MDA)水平和超氧化物歧化酶(SOD)活性,肝脏TC,TG,MDA,SOD。结果:与正常组比较,模型组大鼠FPG,血清HbA1c,血清及肝脏TC,TG,LDL和MDA水平显著升高,血清及肝脏中HDL水平显著降低且SOD活性显著减弱(P<0.05);降脂保肝方可以显著降低糖尿病高血脂大鼠FPG,血清HbA1c,血清及肝脏TC,TG,LDL,MDA水平,提高血清及肝脏中HDL水平和SOD活性(P<0.05)。结论:降脂保肝方可有效调节糖尿病高血脂大鼠糖脂代谢紊乱,降低肝脏脂质水平,提高机体抗氧化能力。Objective： To investigate the effects of Jiangzhi Baoganfang on the metabolic disorders of glucose and lipid in type 2 diabetic rat with hyperlipemia. Method： Type 2 diabetic rat model was established by high-fat diet with tail vein injection of streptozotocin （STZ, 38 mg~ kg-1 ）. Model rats were randomly divided into model group, positive medicine group （metformin 0. 18 g·kg-1）, Jiangzhi Baoganfang group 9.54 g·kg-1 and normal control group. Then the rats were administered with corresponding drugs for 35 days. The fasting plasma glucose （FPG） , glycosylated hemoglobin （HbAle） , total cholesterol （ TC ） , triglyceride （TG） , low density lipoprotein （LDL）, high.density lipoprotein （HDL） , malondialdehyde （MDA） , superoxide dismutase （SOD）, as well as TC, TG, MDA and SOD in liver were measured. Result： Compared with model group, the levels of FPG, HbAle in serum, TC, TG, LDL and MDA in serum and liver were significantly increased while the level of HDL and the activity of SOD in serum and liver were significantly decreased in model group （P 〈 O. 05）. The levels of FPG, HbA1 e in serum, TC, TG, LDL and MDA in serum and liver were significantly reduced while the level of HDL and the activity of SOD in serum and liver was significantly higher in Jiangzhi Baoganfang group （P 〈 0.05 ）. Conclusion： Jiangzhi Baoganfang can adjust the metabolic disorders of glucose and lipid in type 2 diabetic rat with hyperlipemia, decrease the lipid levels in liver and improve the antioxidant capacity.

关 键 词：降脂保肝方 糖尿病高脂血症 糖脂代谢紊乱 丙二醛 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学]