中医疗法对慢性肾功能衰竭患者t-PA,PAI-1的干预作用  

Effect of Traditional Chinese Medicine Therapy on t-PA,PAI-1 to Chronic Renal Failure Patients

作　　者：赵雯红[1] 胡蜀宾 张国瑛[1] 左建娇[1] 

机构地区：[1]石家庄市中医院,石家庄050051

出　　处：《中国实验方剂学杂志》2013年第7期297-299,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省中医药管理局项目(2012160)

摘　　要：目的:探讨中医综合疗法对慢性肾功能衰竭(CRF)患者纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制剂-1(PAI-1)的影响,旨在初步揭示此方法对CRF的可能干预途径。方法:将慢性肾脏病(CKD4)期患者随机分为4组,1组为单纯西药组、2组为西药加中药组、3组为西药加中药加中药灌肠组、4组为西药加中药加中药灌肠加中药熏蒸组,治疗3个月,分别检测各组治疗前后血肌酐、尿素氮、t-PA和PAI-1水平变化。结果:中医综合疗法与单纯西药治疗比较,可明显降低患者血浆PAI-1水平、改善肾功能及升高血浆t-PA水平(P<0.05)。中医综合疗法3组相互比较,4组降低血清肌酐、尿素氮、升高血浆t-PA水平疗效较好(P<0.05),而降低血浆PAI-1水平3组疗法无明显差异(P>0.05)。结论:中医综合疗法可调节机体的纤溶系统,从而达到治疗CRF的目的。Objective： To investigate the effects of traditional Chinese （TCM） medicine therapy on plasminogen activator （t-PA）, plasminogen activator inhibitor （PAI-1） to chronic renal failure （CFR） patients and its intervention way..Method ： The patients of chronic kidney disease （CKD） 4 were randomly divided into 4 groups： western medicine group, western medicine with herbs group, western medicine with herbs and clysis group, and western medicine with herbs, clysis and fumigation group, and treated with the medicine respectively. In the third month, serum creatinine, blood urea nitrogen, plasma t-PA and PAI-1 were detected before and after treatment. Result： In TCM treatments, the levels of plasma PAI-1 were decreased, renal function was improved, and the levels of plasma t-PA were increased significantly as compared to western medicine group （P 〈 0.05 ）. The 4th group decreased the levels of serum creatinine, blood urea nitrogen and increased the levels of plasma t-PA bestly （P 〈 0.05）, but there were no significant differences among the three groups about the decreasing of plasma PAI-1. Conclusion： TCM treatments could intervent CRF by modulating the activity of fibrinolytic system.

关 键 词：中医疗法 慢性肾功能衰竭 纤溶酶原激活物 纤溶酶原激活物抑制剂 

分 类 号：R287[医药卫生—中药学]