降糖精颗粒治疗2型糖尿病疗效观察及机制探讨  

Jiangtangjing Granule Treatment of Type 2 Diabetes Clinical Observation and Mechanism Research

作　　者：曹拥军[1] 陈亚琴[1] 李靖[1] 瞿伟[1] 刘钧[1] 

机构地区：[1]江苏省南通市中医院内分泌科,江苏南通226001

出　　处：《中国实验方剂学杂志》2013年第7期307-309,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察降糖精颗粒治疗2型糖尿病的疗效及其降糖机制的初步探讨。方法:将40例2型糖尿病患者随机分为降糖精组和对照组。通过8周的观察,比较2组患者血糖、糖化血红蛋白(HbAlc)和中医症状积分的变化。结果:2组用药前各项指标无显著差异;用药后,降糖精组空腹血糖、餐后2 h血糖、HbAlc较治疗前比较有统计学差异(P<0.05);与对照组比较无统计学差异。但治疗8周时降糖精组症状明显减轻,与对照组比较有统计学差异(P<0.05)。结论:降糖精颗粒能改善2型糖尿病患者的糖代谢,减轻患者相关中医症状,其机制可能与调节患者的肠促胰素(GLP-1)有关。Objective： To observe the Jiangtangjing granule in effect of treatment for type 2-diabetes and its hypoglycemic mechanism of the initial study. Method ： Forty patients with type 2 diabetes randomly divided into Jiangtangjing group and control group were compared by blood sugar, glycated hemoglobin （HbAlc） and traditional Chinese medicine （TCM） symptoms integral change through the eight weeks observation. Result： There was no significant difference between two groups before using the indicators. After treatment, Jiangtangjing- granule group show significant difference in fasting blood sugar, blood sugar, 2 h postprandial glycosylated hemoglobin （HbAlc） compared with before （P 〈 0. 05）, no statistical difference compared with control group, but the symptoms of Jiangtangjing granule group patients significantly reduced compared with the control group, there was statistically significant （P 〈 0.05 ）. Conclusion： Jiangtangjing granule can improve the glucose metabolism and relieve the symptoms related to TCM of patients with type 2 diabetes. Its mechanism may be related to the level of incretin pancreatic hormone （GLP-1）.

关 键 词：降糖精颗粒 2型糖尿病 胰高血糖素样肽-1 糖代谢 中医症状积分 

分 类 号：R287[医药卫生—中药学]