丹参多酚酸盐对慢性心力衰竭患者心功能及炎症因子的影响  

Effect of Salvianolate Injection on Cardiac Function and Inflammation Factors in Patients with Chronic Heart Failure

作　　者：邱雅慧[1] 薛凌[1] 高夏青[1] 

机构地区：[1]辽宁医学院附属第三医院,辽宁锦州121000

出　　处：《中国实验方剂学杂志》2013年第7期321-323,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察注射用丹参多酚酸盐对慢性心力衰竭(CHF)住院患者心功能及对炎性因子超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)及白介素-6(IL-6)的影响。方法:80例CHF住院患者随机分为观察组和对照组各40例。对照组采用西医常规治疗,治疗组在西医常规治疗的基础上加用丹参多酚酸盐注射液200 mg,溶于5%葡萄糖注射液250 mL静脉滴注,1次/d,疗程14 d。采用Lee氏心衰计分法评价心功能,记录地高辛停减情况,检测hs-CRP,TNF-α及IL-6水平。结果:观察组心衰疗效为95.0%,优于对照组的77.5%(P<0.05);治疗后观察组左室射血分数(LVEF)为(51.3±4.18)%优于对照组的(47.2±4.27)%(P<0.01);观察组地高辛停减率为82.5%优于对照组的57.5%(P<0.05);治疗后观察组hs-CRP,TNF-α及IL-6均低于对照组(P<0.01)。结论:丹参多酚酸盐能改善CHF住院患者心功能,能减少西药的用量,有较好的临床疗效,并能抑制hs-CRP,TNF-α及IL-6炎症因子,减轻心肌损伤。Objective： To observe the effect of salvianolate injection on cardiac function, high sensitivity C reactive protein （hs-CRP）, tumor necrosis factor （TNF-a） and interleukin-6 （IL-6） in patients with chronic heart failure （CHF）. Method： Eighty cases of CHF were randomly divided into the observation group and control group, 40 cases each. The control group was only received western medicine therapy, and the observation group was received western medicine therapy and salvianolate injection （200 mg in 5% glucose injection of 250 mL） iv dropping. The course of treatment of two groups was 14 days. Lee＇ heart failure score method was used to evaluate cardiac function. The termination and decreasing condition of digoxin was recorded, and hs-CRP, TNF-a and IL-6 were determined. Result： There was obvious difference in effective rate between observation group （95.0%） and control group （77.5%） for heart failure （P 〈0.05）. The LVEF in the observation group （51.3±4. 18）% was superior to that in the control group （47.2±4.27） % with a statistical significance （P 〈 0.01 ）. The terminating and decreasing rate of digoxin was 82.5% in the observation group, which was superior to 57.5% in the control group （P 〈0.05）. After treatment, hs-CRP, TNF-a and IL-6 in the observation group were lower than those in the control group （P 〈 0.01）. Conclusion： Salvianolate injection can improve cardiac function in the patients with CHF, reduce the dosages of Western medicines, possess good clinical efficacy, resist inflammatory factors （hs- CRP, TNF-a and IL-6） , and reduce myocardial injury.

关 键 词：丹参多酚酸盐 心力衰竭 心功能 超敏C反应蛋白 肿瘤坏死因子 白介素-6 

分 类 号：R287[医药卫生—中药学]