尿液中11种元素的电感耦合等离子体质谱测定法  

Determination of multi-elements in urine by inductively coupled plasma-mass spectrometry

作　　者：徐赐贤[1] 陈曦[1] 丁亮[1] 林少彬[1] 路凯[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100021

出　　处：《环境与健康杂志》2013年第3期249-252,共4页Journal of Environment and Health

基　　金：科技部卫生行业科研专项项目(201002001)

摘　　要：目的建立尿液中Be、Cr、Mn、Co、Ni、As、Se、Cd、Sb、Tl、Pb 11种元素的电感耦合等离子体质谱测定法。方法分别采用直接稀释法(1%HNO310倍稀释)和微波消解法处理尿液样品,进行ICP-MS分析。采用内标元素补偿基体效应,动态反应池技术消除Cr、Se的质谱干扰,其他元素采用标准模式测定。结果 11种元素在0.01～20μg/L的浓度范围内线性良好,r≥0.999。直接稀释法所得各元素的检出限在0.02～0.58μg/L之间,微波消解法所得各元素的检出限在0.01～0.58μg/L之间。两方法尿样标准参考物质测定结果准确。稀释法各元素的平均回收率为93.8%～116.6%,RSD<9%。结论两种方法均满足测定要求,直接稀释法处理简单,测定快速、准确、灵敏,更适用于大批量尿样中多元素含量的测定。Objective To establish the determination method of Be,Cr,Mn,Co,Ni,As,Se,Cd,Sb,T1 and Pb in urine by inductively coupled plasma-mass spectrometry （ICP-MS）. Methods The urine samples were diluted with 1% HNO3 and digested by microwave with HNO3-H202 at the same time. Then samples were determined by ICP-MS. Internal standard elements were used to compensate for matrix suppression and dynamic reaction cell （DRC） was applied to eliminate the spectral interference of Cr and Se. Other elements were determined with standard method. Results The linear correlation coefficients were ≥0.999 in the range of 0.01-20 μg/L . The limits of detection for dilution method were 0.02-0.58 ttg/L,while the LODs for microwave digestion method were 0.01-0.58 p,g/L. The results of standard reference materials which were determined by two methods fell in the reference range. The rates of recovery the dilution method were 93.8%-116.6%, RSDs were 〈9% . Conclusion The dilution method developed in this study was simple and applicable to rapid and accurate determination of multi-elements content in large quantities urine samples.

关 键 词：电感耦合等离子体质谱 动态反应池 尿液 金属 

分 类 号：O657.6[理学—分析化学]