小儿重型β地中海贫血的中医证候分布规律  

Study on distribution regularity of TCM syndromes of pediatric severe β-thalassemia

作　　者：卢焯明[1] 张春红[1] 陈致雯[1] 王媛媛[1] 范文萃[1] 

机构地区：[1]广州市中医医院儿科,广东广州510130

出　　处：《中医儿科杂志》2013年第2期22-26,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：广东省中医药局课题(2010285)

摘　　要：目的:研究小儿重型β地中海贫血的中医证候分布规律。方法:制定中医证候观察表,对61例重型β地中海贫血患儿进行中医证候调查,并建立数据库,运用聚类分析等统计学手段结合临床判定其证候分布。结果:聚类分析结果聚为四类,分别为肝肾阴虚证(占36.1%)、气血两虚证(占24.6%)、阴阳两虚证(占21.3%)、脾肾阳虚证(占18.0%)。肝肾阴虚证及气血两虚证的血红蛋白(Hb)水平均显著高于阴阳两虚证(P<0.05)。结论:在主要来自于广东省内的小儿重型β地中海贫血患者中,中医证候分布为肝肾阴虚证>气血两虚证>阴阳两虚证>脾肾阳虚证,研究为小儿重型β地中海贫血规范化辨证论治提供了一定依据。Objective： To explore the distribution regularity of TCM syndromes of severe β-thalassemia.Methods： Observation forms of TCM syndromes of thalassemia was made to investigate the TCM syndromes of 61 pediatric cases of severe β-thalassemia and database was established to determine distribution of TCM syndromes by cluster analysis and other methods.Results： Four syndrome patterns of severe β-thalassemia were： deficiency of liver-yin and kidney-yin（36.1%）,deficiency of qi and blood（24.6%）,deficiency of yin and yang（21.3%）,and deficiency of spleen-yang and kidney-yang（18.0%）.Hb values of the patients with deficiency of liver-yin and kidney-yin syndrome and with deficiency of qi and blood syndrome were both significantly higher than those of the patients with deficiency of yin and yang（P0.05）.Conclusion： The distribution of TCM syndromes pattern of severe β-thalassemia in Guangdong province is： deficiency of liver-yin and kidney-yindeficiency of qi and blood deficiency of yin and yang deficiency of spleen-yang and kidney-yang.This study can offer some references for the normative treatment of children with severe β-thalassemia based on TCM syndromes differentiation.

关 键 词：重型Β地中海贫血 中医证候分布规律 聚类分析 

分 类 号：R725.5[医药卫生—儿科]