服用他汀类药物与慢性心力衰竭患者认知功能关系的研究  

Relationship between statins taking and cognitive function in patients with chronic heart failure

作　　者：臧鸿斌[1] 李晓东[1] 

机构地区：[1]中国医科大学附属盛京医院心内科,沈阳110004

出　　处：《实用药物与临床》2013年第3期221-223,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨他汀类药物治疗对慢性心衰患者认知功能的影响。方法入选70例NYHAⅡ～Ⅳ级、左室射血分数<45%的慢性心衰患者为观察对象。其中连续服用他汀类药物3个月的35例慢性心衰患者进入他汀组,35例未服用他汀类药物的慢性心衰患者进入对照组。使用简易智能量表(Mini-Mental State Examina-tion,MMSE)评估两组入选时及入选3个月后的认知功能情况。结果他汀组与对照组在筛选及3个月后随访时,MMSE评分差异无统计学意义(P=0.78,P=0.77);两组间随访前后认知功能障碍比率比较差异无统计学意义(P=0.75,P=0.38);两组内入选及随访认知功能障碍比率比较差异无统计学意义(P=0.74,P=0.57)。结论本研究未能发现他汀类药物可改善慢性心衰患者认知功能,提示短期服用他汀类药物不能改善慢性心衰患者认知功能。Objective To identify the effect of statins taking on cognitive function in patients with chronic heart failure. Methods 70 patients with chronic heart failure（NYHA Ⅱ～Ⅳ）,whose left ventricular ejection fractions were lower than 45%,were included.35 patients who had continuously taken statins for 3 months were enrolled in the statins therapy group,and the others who had not taken statins were enrolled in the control group.Then Mini-Mental State Examination（MMSE）were used to evalue the cognition function at the time of screening and after 3 months follow-up. Results There was no significant difference in MMSE scores between statins therapy group and control group at the time of screening（P=0.78）and after 3 months follow-up（P=0.77）.The ratio of cognition impairment had no significant differentce between the two groups（P=0.74,P=0.57）.In each group,there was no significant difference in MMSE scores at the time of screening and after 3 months follow-up（P=0.74,P=0.57）. Conclusion The study has failed to prove that statins could improve the cognitive function of patients with chronic heart failure,suggests that short-term statins therapy could not improve cognitive function in patients with chronic heart failure.

关 键 词：慢性心功能衰竭 认知功能障碍 简易智能量表 他汀类药物 

分 类 号：R541.6[医药卫生—心血管疾病]