卡马西平致过敏反应综合征一例  

Hypersensitive syndrome induced by carbamazepine

作　　者：李坚[1] 赵淑清[1] 

机构地区：[1]北京大学第三医院神经科,北京100191

出　　处：《实用药物与临床》2013年第3期268-269,共2页Practical Pharmacy and Clinical Remedies

摘　　要：患者,女,68岁,因三叉神经痛口服卡马西平,剂量从0.1 g,bid逐渐增至0.2 g,bid,第16天出现颌下、颈部淋巴结肿大;第28天出现发热、皮疹;第35天停药热退;第39天胃与食道不适、吞咽困难、内痔出血,3d后好转;皮疹1月余消退,后遗皮肤色素沉着及淋巴结肿大。A 68-year-old female patient with trigeminal neuralgia received carbamazepine, which dosage was increased from 0. 1 g twice daily to 0. 2 g twice daily. 16 d later,the patient experienced lymphadenectasis in submaxillary and jugular regions. 28 d later, the patient had a fever and crops. 35 d later, the drug was discontinued, her temperature got right. 39 d later, the patient felt dysphagia and comfortlessness in esophagus and stomach,in the meantime, the patient found bleeding from existing internal hemorrhoid, which lasted for 3 days. Deflorescence appeared after over a month. The patient recovered with cutaneous pigmentation and lymphadenectasis.

关 键 词：卡马西平 过敏反应综合征 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]