益肾调气法治疗产后抑郁症的随机对照临床研究  

Replenishing kidney and regulating qi therapy for postpartum depression: a randomized controlled trial

作　　者：许芳[1] 唐启盛[2] 李小黎[2] 

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学第三附属医院,北京100029

出　　处：《北京中医药》2013年第3期200-203,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：科技部国际科技合作项目资助(2010DFA30950);北京中医药大学创新团队项目资助(2011-CXTD-26)

摘　　要：目的观察益肾调气法对产后抑郁症肾虚肝郁型患者的疗效。方法将201例患者采取随机、对照、盲法的原则分为中药、针灸、中药+针灸与安慰剂组,使用《中医证候量表症状评定表》和爱丁堡产后抑郁量表(EPDS)评定中医药治疗的有效率,测定治疗前后血清雌二醇及孕酮水平的差值。结果中医证候及EPDS量表疗效,中药组、中药+针灸组在治疗第2、4、6周的总有效率优于安慰剂组(P<0.01),而针灸组仅在治疗的第4、6周总有效率优于安慰剂组(P<0.05)。治疗前后血清雌二醇、孕酮水平的差值,与安慰剂组比较,中药组、针灸组、中药+针灸组的差异均具有统计学意义(P<0.05);中药+针灸组较单独使用中药或针灸组雌二醇差异具有统计学意义(P<0.05),较单独使用中药组孕酮差异具有统计学意义(P<0.05)。结论益肾调气法治疗肾虚肝郁型产后抑郁症疗效显著,其作用机制可能与调节体内激素水平有关。Objective To observe the efficacy of the replenishing kidney and regulating qi therapy on postpartum depression in the syndrome of kidney-deficiency and liver-depression. Methods According to randomized, controlled and blinding principle, two hundred and one cases were divided into a Chinese medicinal group, an acupuncture and moxibustion group, a Chinese medicinal＋acupuncture and moxibustion group and a placebo group. The effective rate of TCM treatment was evaluated by symptom evaluation of TCM syndrome scale and Edinburgh Postnatal Depression Scale （EPDS） and the differences of serum estradiol and progesterone level before and after treatment were measured. Results According to TCM syndrome and EPDS scales, the total effective rates after 2,4,6 weeks of the treatment in the Chinese medicinal group and the Chinese medicinal＋acupuncture and moxibustion group were superior to those in the placebo group （P 〈 0.01）, while the total effective rates after the treatment for only 4,6 weeks in the acupuncture and moxibustion group were superior to those in the placebo group （P 〈 0.05）. Compared with the placebo group, the differences of serum estradiol and progesterone level before and after treatment were both statistically significant in the other groups （P 〈 0.05）. The difference of serum estradiol in the Chinese medicinal＋acupuncture and moxibustion group was statistically significant compared with that in the Chinese medicinal group or the acupuncture and moxibustion group （P 〈 0.05）, and the difference of progesterone level was statistically significant compared with that in the Chinese medicinal group （P 〈 0.05）. Conclusion The replenishing kidney and regulating qi therapy has a remarkable effect on postpartum depression in the syndrome of kidney-deficiency and liver-depression and its mechanism might be related to adjusting hormone levels.

关 键 词：益肾调气法 产后抑郁 临床研究 

分 类 号：R271.9[医药卫生—中西医结合]