利用荷移反应分光光度法测定头孢曲松钠  

Spectrophotometric determination of ceftriaxone sodium with charge-transfer reaction

作　　者：宋健玲[1] 谢鲜梅[1] 

机构地区：[1]太原理工大学化学化工学院,太原030024

出　　处：《分析仪器》2013年第2期15-18,共4页Analytical Instrumentation

基　　金：国家自然科学基金(No.50872086);山西省自然科学基金(No.2008011018)资助项目

摘　　要：研究了头孢曲松钠与对苯醌的荷移反应,、确定了形成电荷转移络合物的最佳反应条件。在硼砂介质中,电子给予体头孢曲松钠与电子接受体对苯醌于室温下可形成1∶2的荷移络合物,络合物的最大吸收波长为606.0nm;表观摩尔吸光系数ε=1.73×104 L.mol-1.cm-1;线性范围为2μg/mL～24μg/mL;对形成荷移络合物的机理进行了探讨,并应用拟定的方法对注射用头孢曲松钠样品进行了含量测定,回收率为98.64%～100.7%;RSD≤1.03%。The charge-transfer reaction between ceftriaxone sodium and p-benzoquinone has been studied spectrophotometrically. The optimization of experimental conditions on the formation of charge transfer complex was performed. At room temperature, ceftriaxone sodium reacts with p-benzoquinone in borax buffer solution and forms a 1 ： 2 complex with apparentmolar absorptivity of 1.73×10^4 L · mo1-^1 · cm^-1 at 606.0 nm, Beer＇s Law is obeyed in the range of 2- 24υg/mL of ceftriaxone sodium with a correlation coefficient of 0. 9998. The proposed method was applied to the determination of ceftriaxone sodium for injection and satisfactory results have been obtained. The recovery is 98. 64 %- 100. 7 % and the relative standard deviation is 1.03%.

关 键 词：荷移反应 分光光度法 头孢曲松钠 对苯醌 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.3[化学工程—制药化工]