替比夫定对慢性乙型肝炎患者血清sIL-2R及球蛋白水平的影响  

The Effect of Telbivudine on the Levels of Serum SIL-2R and GLB in Patients with Chronic Hepatitis B

作　　者：王海燕[1] 王煜 王琦[1] 闫跃武[1] 刘娅 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大总医院感染性疾病科,银川750004

出　　处：《宁夏医科大学学报》2013年第2期161-163,共3页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金(NZ10118)

摘　　要：目的观察替比夫定治疗慢性乙型肝炎(CHB)患者过程中血清可溶性白细胞介素2受体(sIL-2R)和球蛋白(GLB)的水平变化,探讨替比夫定抗乙型肝炎病毒(HBV)的免疫调节作用。方法选择应用替比夫定治疗的CHB患者30例及健康体检者30例,检测CHB治疗前、治疗后4、12、24周患者血清sIL-2R、GLB、乙型肝炎病毒脱氧核糖核酸(HBV-DNA)及丙氨酸转移酶(ALT)等水平。结果患者血清sIL-2R和球蛋白水平明显高于正常对照组(P<0.01);经替比夫定治疗后,患者血清sIL-2R含量在治疗4周时升高,治疗12周时有所下降,治疗24周时再次升高,且治疗期间均高于健康组基线水平。球蛋白水平从第4周开始随治疗时间延长明显下降,ALT及HBV-DNA水平随治疗时间的延长均逐渐下降(P<0.05)。结论替比夫定除有效抑制HBV复制外,可动态调节血清sIL-2R及GLB含量,参与机体免疫调节。Objective To observe the effect of telbivudine on serum sIL-2R and GLB in patients with chronic hepatitis B（CHB）,and to investigate the immune regulation of telbivudine＇s anti-HBV.Methods 30 patients with CHB accepted telbivudine treatment and 30 healthy volunteers were selected.The levels of serum sIL-2R,GLB,ALT,HBV-DNA load were detected before and at 4th weeks,12th weeks,24th weeks after telbivudine treatment.Results The levels of serum sIL-2R and GLB were significantly higher compared with the levels of healthy volunteer group（P0.01）.After the treating,the level of serum sIL-2R in patients raised at 4th week,then decreased at 12th week and then increased at 24th week.The level of serum GLB significantly reduced at 4th week.The levels of ALT and HBV-DNA load fallen as time went on（P0.05）.Conclusion Telbivudine not only suppress HBV duplication,but also it may dynamically adjust the levels of sIL-2R and GLB in patients with CHB and take part in immune function adjustment.

关 键 词：替比夫定 慢性乙型肝炎 血清可溶性白细胞介素2受体 球蛋白 

分 类 号：R512.62[医药卫生—内科学]