以反丁烯二酸合成的不饱和脂肪族聚酯的生物降解性研究  

Biodegradability of unsaturated aliphatic polyesters prepared from fumaric acid

作　　者：杨群[1] 陆大年[1] 崔进 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620 [2]上海伊纯实业有限公司,上海201600

出　　处：《应用化工》2013年第3期490-494,共5页Applied Chemical Industry

摘　　要：以反丁烯二酸、一缩二乙二醇和1,4-丁二醇为原料,采用熔融缩聚法合成了不饱和脂肪族聚酯和共聚酯,在37℃下,用含有脂肪酶的磷酸缓冲溶液对聚酯的生物降解性进行了研究,讨论了聚酯结构、组成及C=C双键的交联度对生物降解性的影响。结果表明,对于粘稠液体状的聚酯,C=C双键的引入,没有明显的改变其生物降解性;对于固体状的聚酯,C=C双键引入后,熔点(Tm)和结晶度增加;聚酯部分降解后,其热力学性能(Tm、-ΔHm)和结晶度都升高;对于交联后的聚酯,交联度越高,生物降解性越差。Unsaturated aliphatic polyesters and copolyesters were prepared fi＇om fumaric acid （ FA）, dieth- ylene glycol （DEG） and 1,4-butanediol （BD） by melt polycondensation method. Enzymatic degradation was performed at 37℃ in phosphate buffer solution with porcine pancreas lipase, effect of structures, compositions and cross-linking degrees of carbon-carbon double bonds of polyesters on the biodegradability were discussed. The results indicated that, as the C=C double bond introduced into the backbone of solid polyesters, T value and crystallinity increased. The degradability of aliphatic polyesters by lipases depended strongly on their Tm values and crystallinity, the higher the Tm and crystallinity, the lower the de- gradability. The result also indicated that the thermal properties （ Tm value and - AH, o value） and crystallinity of polyesters increased after partially enzymatic degradation, the biodegradation of unsaturated all- phatic polyester became smaller after cross-linked, biodegradation. and the higher the cross-linking degree, the smaller the

关 键 词：不饱和脂肪族聚酯 熔融聚合 生物降解性 交联度 共聚酯 

分 类 号：TQ317.4[化学工程—高聚物工业]