胆甾醇辛酸酯-辛酰基-1-^(13)C的合成  

Synthesis of Cholesteryl Octanoate-octanoyl-1-^(13)C

作　　者：卢伟京[1] 李帅[1] 徐仲杰[1] 卢浩[1] 

机构地区：[1]上海化工研究院,上海200062

出　　处：《同位素》2013年第1期60-64,共5页Journal of Isotopes

基　　金：国家高技术研究发展计划项目(2008AA02Z427)

摘　　要：采用缩合与催化的组合方式,利用胆固醇(Ch-OH)与辛酸-1-13 C反应,合成胆甾醇辛酸酯-辛酰基-1-13 C(ChO-13 C),产率84.1%,13 C丰度99.0%,光学纯度99.0%,化学纯度99.5%。用HPLC-ELSD、LC-MS和1 H NMR对产品进行表征,确定产品为胆甾醇辛酸酯结构。Cholesteryl octanoate-octanoyl-1-13C was synthesized by a method of coupling-catalysis.The yield of 13C labeled Cholesteryl octanoate was 84.1%（based on Cholesterol）,with 99.0% atom 13C 99.0% optical purity and 99.5% chemical purity.The product was characterized by HPLC-ELSD,LC-MS and 1H NMR.The structure and 13C isotopic enrichment of it was determined and measured by LC-MS and 1H NMR.

关 键 词：胆甾醇辛酸酯-辛酰基-1-13C 合成 13C标记 呼吸试剂 

分 类 号：O612.4[理学—无机化学]