睾丸生殖细胞的凋亡及其调控  

Germ Cell Apoptosis and Regulation in Testis

作　　者：郭彩霞[1] 唐铁山[2] 刘以训[1] 

机构地区：[1]中国科学院动物研究所生殖生物学国家重点实验室 [2]中国科学院发育生物学研究所,北京100080

出　　处：《生理科学进展》2000年第4期299-304,共6页Progress in Physiological Sciences

基　　金：<国家重点基础研究发展规划>;<攀登预选项目>;自然科学基金项目!(37870 368)资助

摘　　要：睾丸生殖细胞在分化过程中存在自发性和诱发性凋亡 ,这是清除过量或异常生殖细胞的一种重要途径。生殖细胞的凋亡涉及内分泌、细胞社会组成和基因等多因素的调控。深入了解生殖细胞凋亡的调控机制 ,明确决定睾丸生殖细胞 (Germcells,Gc)凋亡机制的分子组成 。Both spontaneous and induced germ cell apoptosis occur during the process of germ cell differentiation in testis, which is an important mechanism to remove surplus and abnormal germ cells. It has been known that germ cell apoptosis is under the control of endocrine, cell social association and gene. To elucidate the molecular mechanisms by which germ cell apoptosis is regulated and the elements of the death machinery will provide a basis for effective management of male infertility as well as more targeted approaches to male contraception.

关 键 词：睾丸生殖细胞 细胞凋亡 精子发生 调控机制 

分 类 号：Q492.4[生物学—生理学] R339.28[医药卫生—人体生理学]