聚乙二醇硬脂酸酯15对黄芩苷角膜透过性研究  

Investigation on corneal permeability for Baicalin of SolutolHS 15 in vitro

作　　者：张锐[1,2] 赵海南[1,2] 瞿继兰[1,2] 李琳[1,2] 李楠[1,2] 刘志东[1,2] 

机构地区：[1]天津中医药大学,天津市现代中药重点实验室-省部共建国家重点实验室培育基地 [2]现代中药发现与制剂技术教育部工程研究中心,300193

出　　处：《天津中医药大学学报》2013年第1期36-39,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81001645);中国博士后科学基金项目(20090460701)

摘　　要：[目的]研究聚乙二醇硬脂酸酯15(Sol)对黄芩苷离体角膜透过率的影响,探讨其在眼用制剂中的应用。[方法]采用离体角膜渗透技术考察不同质量浓度的Sol对黄芩苷角膜透过率的影响。[结果]0.4%和0.8%的Sol使黄芩苷的表观渗透系数分别增加了2.05倍和1.65倍,与对照组相比差异有统计学意义(P<0.05),而0.2%、1.0%和2.0%的Sol未能显著增大黄芩苷的表观渗透系数(P>0.05)。[结论]0.4%和0.8%的Sol能够显著增大Sol的表观渗透系数,且对角膜无刺激性。[Objective] To investigate the effect of SolutolHS 15 （Sol） on corneal preparation rate and to explore their use in ophthalmology. [Methods] The effects of Sol on the corneal permeability for Baicalin were investigated in vitro with isolated corneas of rabbit. [Results] The 0.4% and 0.8% Sol could increase the appeared permeability for Baicalin as much as 2.05 and 1.65 times respectively when compared with the permeability in control （P〈0.05）. However, 0.2%, 1.0% and 2.0% Sol could not improve the appeared permeability for Baicalin（P〉0.05）. [Conclusion] The 0.4% and 0.8% Sol can enhance the corneal appeared permeability for Baicalin significantly and have not irritation on eye tissues.

关 键 词：聚乙二醇硬脂酸酯15 角膜透过性 黄芩苷 

分 类 号：R285.5[医药卫生—中药学]