中枢外源性胃动素对大鼠脑干胃相关神经元电活动及胃运动的影响  

Effect of central administration of motilin on the activity of gastric-related neurons in brain stem and gastric motility of rats

作　　者：唐明[1] 张洪燕[1] 蒋正尧[1] 徐珞[1] T.L.Peeters 

机构地区：[1]青岛大学医学院生理教研室,青岛266021 [2]比利时鲁汶大学胃肠激素研究室

出　　处：《生理学报》2000年第5期416-420,共5页Acta Physiologica Sinica

基　　金：Supported by the National Natural Science Foundation of China(No.39970280);Bilateral Scientific and Technological Cooperation Program Between China and Flanders(BWTS97/38)

摘　　要：用核团或侧脑室微量注射、微电极细胞外单位放电记录及清醒动物胃运动记录等方法 ,观察了大鼠下丘脑腹内侧区 (ventralmedialhypothalamus,VMH)或侧脑室内 (icv)微量注入胃动素 (motilin)对延髓迷走复合体 (dorsalvagalcomplex ,DVC)神经元电活动和胃运动的影响。结果表明 :(1)VMH注入胃动素会改变DVC胃相关神经元的电活动 ;(2 )VMH及侧脑室内注入胃动素可使清醒大鼠胃运动增强 ;(3)膈下迷走神经切断会取消VMH增强胃运动的作用。上述结果提示 ,中枢注入的胃动素可能作为促进胃运动的调节因子参与中枢增强胃肠的调控 ,下丘脑 延髓To investigate the effect of microinjection of motilin into ventral medail hypothalamus (VMH) or intracerebroventricle (icv) on gastric motility, extracellular unit responses of dorsal vagal complex (DVC) in anesthetized rats and gastric motility of conscious rats were recorded. The results are as follows. (1) The firing rate of gastric distention related neurons in DVC was modified. (2) VMH and icv administration of motilin induced obvious enhancement in gastric motility. (3) The effect of motilin on gastric motility was abolished by vagotomy. These results imply that central motilin appears to work as an excitatory neuromodulator in the regulation of gastric motility through VMH DVC vagal nerve axis.[WT5HZ]

关 键 词：胃动素 胃运动 下丘脑腹内侧核 

分 类 号：Q482[生物学—生理学] Q426