不育不孕症生殖道衣原体及支原体的感染  

A study of infertility and genital tract infection by chlamydia and mycoplasma

作　　者：陈栋[1] 邓列华[2] 章岳娟[1] 陆涛[2] 王婕玲[2] 李克俭[2] 

机构地区：[1]暨南大学医学院第一附属医院新医科,广东广州510630 [2]暨南大学医学院第一附属医院皮肤科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2000年第4期121-125,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的 :了解不育不孕症生殖道衣原体及支原体的感染及其与年龄、性别、原发性、继发性、不洁性接触史的关系 ;解脲支原体 (UU)感染、生殖道炎症与精子活动率、抗精子抗体 (AsAb)的关系 ,进一步探讨不育不孕的致病因素 ,提高诊断准确率和治愈率。方法 :选用衣原体检测及支原体培养技术、抗精子抗体 (AsAb)检测技术、明胶凝集试验 (GelatingAgglutinationTest,GAT) ,试管玻片凝集试验 (TubeslideAgglutinationTest,TSAT)、精液分析检查。结果 :2 12例不育不孕症和 196例正常育龄夫妇的生殖道分泌物支原体、衣原体感染检测结果表明 ,男性不育的尿道感染率为 4 6 0 3% ;女性不孕的宫颈感染率为 52 32 % ,皆明显高于对照组 ,但差异无显著性意义。 2 5～ 2 9岁年龄段的感染率为 4 7 12 % ,与对照组比较 ,差异有极显著性意义 (P <0 0 0 5) ,解脲支原体 (UU)感染的不育不孕症的抗精子抗体 (AsAb)阳性发病率明显高于非感染者 (P <0 0 0 1)。解脲支原体感染的原发性与继发性不育比较 ,差异无显著性意义。伴有前列腺炎或宫颈炎与非炎症者的解脲支原体感染率无明显差异 ,而有不洁性接触史者发病率普遍高 ,与无不洁性接触史者感染率相比差异无显著性意义。结论 :解脲支原体感染在不育不孕症支原体衣原体感染中的感?Aim:To study (1) the relationship between genital tract infection with chamydia & mycoplasma in infertility and age group,primary or sccondary infertility, unsafe sexual contact;(2) the relationship between(UU)infection and genital inflammation,sperm activity AsAb(antisperm antibody),so that to asscss the causal factors in infertility and try to confirm the etiology and increase the detection and cure rate.Methods: Use:(1) chlamydial detection technique;(2) mycoplasma culture technique;(3) antisperm antibody assay;(4) Gelating Agglutination Test,GAT;(5) Tube Slide Agglutination Test,TSAT;(6) seminal analysis. Results: The genital tract secretion of 212 cases of infertility patient and 196 normal productive age patient were use for detection of chlamydial and mycoplasmal infection.Urcthral infection rate was 46.03% in male infertility patient.Cervical infection rate was 52.2%in female infertility patients.Both higher than control group,but the difference is not significant.The infection rate in 25～29 year old age group was 47.12%,had singnificant difference( P <0.005) as compare with control group.A tisperm antibody positive rate is marked higher in UU infected group.No significant difference in UU infection between primary and secondary infertility. There was no difference in UU infection rate between inflammatory(with prostatitis/cervical inflammation)or non-inflammatory group(without prostatitis/cervical inflammation).High UU infection rate in unsafe sexual contact group but has no significant difference between safety sex group and unsafe sex group. Conclusion: Urea spiting mycoplasma(UU) infection is the commonest organism in infertility associated with mycoplasma & chlamydia infection which affect sperm activity and Antisperm antibody(AsAb).25～29 year old group had UU infection rate higher than control group,suggested incidence trend to occur in younger age group.There were no significant difference between sex,primary or secondsry infertility safety and unsafety sexual contact history. Therefore,n

关 键 词：不育不孕症 衣原体感染 支原体感染 生殖道感染 

分 类 号：R711.6[医药卫生—妇产科学] R759[医药卫生—临床医学]