大鼠心肌梗死模型心肌肌钙蛋白T动态变化规律研究  

Dynamic changes of cardiac troponin T in rat myocardial infarction model

作　　者：李贻奎[1] 李峰杰[1] 张萍[2] 赵乐[1] 余学钊[1] 郝伟[1] 

机构地区：[1]中国中医科学院西苑医院实验研究中心,北京100091 [2]中国中医科学院西苑医院高干科,北京100091

出　　处：《中国药理学通报》2012年第10期1356-1359,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金-青年科学基金资助项目(No30801531)

摘　　要：目的探讨心肌肌钙蛋白T(cTn-T)在大鼠急性心肌梗死模型中的动态变化规律。方法大鼠分为正常组、模型组;模型组结扎冠状动脉制作大鼠心肌梗死模型,于结扎前、结扎后1、2、3、4、6、12、24 h、3、5、7 d眼球后静脉丛取血,测定血清中cTnT含量。结果与正常组比较,大鼠急性心肌梗死后,血清cTn-T含量在3 h开始升高,差异具有显著性(P<0.05),6 h达到高峰,差异具有显著性(P<0.01),且一直持续到术后7 d。结论结扎冠状动脉造成大鼠急性心肌梗死模型后,血清cTn-T含量在3h开始升高,6h达到高峰,可作为急性心肌梗死特异性检测指标。Aim To study the dynamic changes of cardiac troponin T in rat myocardial infarction model.Methods Rats were randomly divided into normal group and model group.The model group rats were given coronary artery ligation to induce rat myocardial infarction model.On the day before the surgery and 1,2,3,4,6,12,24 h,3,5,7 d after myocardial infarction,the content of cTn-T was detected in blood from retrobulbar venous plexus.Results After acute myocardial infarction,the cTn-T content of the model group began to increase at 3 h,and compared with the normal group,the difference was significant（P 0.05）;at 6 h,the cTn-T content reached a peak,and compared with the normal group,the difference was highly significant（P 0.01）.Conclusions After acute myocardial infarction,the cTn-T content begins to increase at 3 h,reaching a peak at 6 h.The cTn-T can be used as specificity detection indicator of acute myocardial infarction.

关 键 词：急性心肌梗死 模型 结扎 心肌肌钙蛋白T 变化规律 大鼠 

分 类 号：R332[医药卫生—人体生理学] R341[医药卫生—基础医学]