缝隙连接可能是吸入全麻药作用的分子靶位之一  

Gap junctions may participate in the mechanism of action of inhalational anesthetics

作　　者：陈章燕[1] 黎尚荣[1] 

机构地区：[1]中山大学附属第三医院麻醉科,广州510630

出　　处：《国际麻醉学与复苏杂志》2013年第4期371-374,共4页International Journal of Anesthesiology and Resuscitation

基　　金：基金项目：广东省自然科学基金（9151008901000192）

摘　　要：背景吸入麻醉药已在临床广泛应用，但其作用机理至今尚未明确。而缝隙连接（gap junctions，GJ）也是神经系统介导细胞间信息传递的重要方式，可能是吸入全麻药作用的分子靶位之一。目的分析推测GJ及其介导的细胞间传递是否参与吸入全麻药的麻醉作用。内容阐述吸入麻醉药的机制，GJ在中枢神经系统中的结构、分布、功能以及与吸入麻醉药作用的关系。趋向研究GJ及其介导的细胞间传递能为今后研究全麻药的作用机制提供新方向。Background Inhalational anesthetics have been widely used in clinical anesthesia for a wide range of surgeries. But the mechanism of anesthetic actions is still not clear. Gap junctions （GJ） are important ways of information delivery among mediate cells in nervous system. Perhaps it is one of the molecular sites of inhalational anesthetic action. Objective The purpose of this article is to investigate whether GJ and GJ mediated intercellular communication may participate in the mechanism of action of inhalational anesthetics or not. Content The mechanism of action of inhalational anesthetics has been analyzed. Moreover, the structure, distribution and function of GJ and its relationship with inhalational anesthetics in the central nervous system were also described. Trend The research about GJ and the intercellular communication mediated by GJ is a new direction to explore the anesthetic mechanism.

关 键 词：缝隙连接 吸入麻醉药 作用机制 

分 类 号：R614[医药卫生—麻醉学]