炎症调控介质：保护素D1的研究进展  

Protectin D1： an update on endogenous regulators of inflammation

作　　者：郭丽娜[1] 舒化青[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,武汉430022

出　　处：《国际麻醉学与复苏杂志》2013年第4期375-378,共4页International Journal of Anesthesiology and Resuscitation

基　　金：基金项目：湖北省卫生厅基金资助项目（02.07.060234）

摘　　要：背景保护素D1（protectin D1，PD1）是近期发现的由二十二碳六烯酸（docosahexenoic acid，DHA）衍生的生物活性分子，是机体一种重要的内源性脂质抗炎及促炎症消退介质。目的深入认识这个新的家族有助于探讨多种疾病的发病机制，并为其治疗提供新的靶点。内容大量研究表明，PD1对多种炎性细胞的功能和多种炎症相关基因的表达有广泛的调节作用，能促进炎症反应及时消退，可改善多种疾病的转归。现就PD1的生物学活性、对炎性细胞及炎症相关疾病的作用作一综述。趋向随着研究的深入，必将全面地揭示PD1的病理生理意义、详细地阐明其效应机理，并最终研制出具有临床应用价值的新型抗炎药物。Background Protectin D1 （PD1） is a new bioactive molecule derived from docosahexenoic acid （DHA）, it is an important kind of endogenous lipid anti-inflammatory and pro-resolution medium. Objective Expanded understanding of PD1 contributes to investigate the pathogenesis of a variety of diseases and provide new targets for its treatment. Content Numerous studies suggest that PD1 can act on inflammatory ceUs and inflammatory-related genes, and improve the prognosis of many kinds of diseases, activate inflammation-resolution programmes. This review presents an update and overview of PD1 about its biological activity and its effects on inflammatory cells and inflammatory diseases. Trend With further research, it will fully reveal the pathophysiological significance of the PDI and clarify the mechanism of its effects. It is thought that people will open up the clinical value of new anti-inflammatory drugs based on PD1.

关 键 词：保护素D1 炎症 脂质介质 炎症消退 

分 类 号：R9[医药卫生—药学]