不同强度噪声对高血压患者肾素活性和醛固酮的影响  

Effects of noise of different intensity on plasma renin activity and aldosterone in patients with hypertension

作　　者：杨绿舜 黄龙[2] 彭光义 陈健聪 

机构地区：[1]深圳市龙华新区人民医院牛栏前社康中心,广东深圳518131 [2]广东省深圳市宝安区西乡人民医院检验科,广东深圳518102 [3]广东省深圳市宝安区福永预防保健所门诊部,广东深圳518103

出　　处：《广州医学院学报》2012年第6期22-25,共4页Academic Journal of Guangzhou Medical College

基　　金：深圳市宝安区科技计划社会公益科研资助项目(20110454)

摘　　要：目的:探讨不同强度的噪声对高血压患者肾素活性(PRA)和醛固酮(ALD)的影响。方法:选取从事与噪声相关职业的高血压患者1150例作为研究对象,检测其接触不同强度噪声后血浆PRA和ALD水平。结果:在接触噪声强度<80 dB的高血压患者中,实验前及实验6、12个月后PRA和ALD浓度比较,差异均无统计学意义(P>0.05);在接触噪声强度>80dB的高血压患者中,实验12个月后PRA和ALD浓度均较实验前明显升高(P<0.05);相同噪声干预高血压患者,12个月后基础血压越高,PRA和ALD的水平也越高(P<0.05)。结论:80dB强度的噪声的干预使高血压患者血浆中PRA和ALD水平升高。Objective：To determine the effects of noise of different intensity on plasma rennin activity （PRA） and aldosterone （ALD） in patients with hypertension. Methods： A total of 1150 patients with occupational noise-associated hypertension were included for assessment of PRA and ALD following exposure to the noise. Results ： Patients with hypertension who were exposed to noise 〈 80 dB, the levels of PRA and ALD did not differ statistically at months 6 and 12 （ both P 〉 0.05 ）. Those who were exposed to noise 〉 80 dB presented an impressively elevated PRA and ALD at month 12 （ both P 〈 0.05 ）. Additionally, higher blood pressure was linked to higher levels of PRA and ALD at month 12 given the same intensity of noise （P 〈0.05 ）. Conclusion： Increased PRA and ALD, the resuhs linked to baseline blood pressure, may be associated with the exposure to noise 〉 80 dB in patients with hypertension.

关 键 词：噪声 高血压 肾素 醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病]