贵州省708例尿路结石成分分析  

Biochemical compositions of urinary calculi in Guizhou province: analysis on 708 cases

作　　者：石华[1] 徐述雄[2] 李凯[2] 王晓东[2] 王元林[2] 孙兆林[2] 熊鸿燕[1] 

机构地区：[1]第三军医大学军事预防医学院军队流行病学教研室,重庆400038 [2]贵州省人民医院泌尿外科,贵阳550002

出　　处：《第三军医大学学报》2013年第7期657-660,共4页Journal of Third Military Medical University

基　　金：国家自然科学基金(81260112);贵州省优秀科技教育人才省长资金项目[黔省专合字(2009)31];贵州省科技厅-贵州省人民医院联合基金[黔科合LS(2012)007]~~

摘　　要：目的分析尿石症患者的尿路结石化学成分及其分布特征。方法回顾性分析贵州省人民医院泌尿外科2009年12月至2012年9月共708例尿石症病例,以红外光谱法分析尿路结石的化学成分,并以患者性别、年龄、结石部位等为分组依据,分析各组尿路结石的化学成分特征。结果 40～<60岁组尿路结石发病率达高峰,男性与女性尿路结石患者的比率为1.97∶1;结石成分检出率最高的为草酸钙(占94.77%);其次是碳酸磷灰石(占38.70%),尿酸或尿酸铵(13.42%)、磷酸镁铵(3.53%)、磷酸氢钙(0.56%)、胱氨酸(0.28%)等成分结石所占比例较低。结论贵州省尿石症患者的尿路结石化学成分以草酸钙为主,草酸钙结石所占比率高于国内其他省份,有必要深入开展防治措施研究。Objective To analyze the biochemical stone compositions of urinary calculi and investi- gate the distribution in general population of Guizhou province. Methods Clinical data of 708 patients with identified urinary calculi living in Guizhou province admitted in the provincial hospital from December 2009 to September 2012 were retrospectively collected. Infrared spectrophotometry was carried out for biochemical composition analysis of urinary stones retrieved by endoscopic, open surgery, or spontaneously or by extracorpo- real shock wave lithotripsy. Gender, age and stone location among these patients were evaluated, and the results were analyzed with biochemical stone analysis. Results Urinary calculi were most common in the patients at the age of 40 to 60, and with an incidence of male to female of 1.97： 1. The most dominant composi- tion of urinary stones was calcium oxalate （94.77%）, followed by carbonate apatite （38.70%）, uric acid or ammonium urate （13. 42%）, ammonium magnesium phosphate （3. 53% ）, calcium hydrophosphate （0. 56% ）, and cystine （0.28%）. Conclusion The dominant stone composition in inhabitants of Guizhou province is calcium oxalate, which significantly higher than other regions of China. Some special measures should be taken to prevent urolithiasis in Guizhou province.

关 键 词：结石分析 尿路结石 结石成分 

分 类 号：R181.34[医药卫生—流行病学] R691.4[医药卫生—公共卫生与预防医学]