非甾体抗炎药物注射制剂的开发与临床应用  

Preparation development and clinical application of non-steroidal anti-inflammatory injections

作　　者：李健和[1] 胡焰[2] 曹俊华[3] 易利丹[1] 彭六保[1] 

机构地区：[1]中南大学湘雅二医院药学部,湖南长沙410011 [2]中南大学药学院,湖南长沙410013 [3]湖南省马王堆医院,湖南长沙410016

出　　处：《中国新药与临床杂志》2013年第3期167-176,共10页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：非甾体抗炎药物注射制剂的临床试验结果表明其镇痛、解热、抗炎作用良好,不良反应少,为不能服用口服制剂的患者提供了选择空间。但目前有些研究涉及的患者数量相对较少,治疗时间也相对较短,使其不良反应难以察觉,故上市后的监测将至关重要。本文综述了非甾体抗炎药物注射制剂的研究进展,供临床和新药研发参考,以促进临床安全合理用药。The results of clinical trials showed that intravenous non steroidal anti inflammatory agentshad good analgesic, antipyretic and anti inflammatory effects and less adverse reactions. They can provide a space of selection for patients who can not take oral agents. However, some studies involved relatively small patient numbers and relatively short treatment time, making it difficult to detect adverse reactions. So the post marketing surveillance will be vital. This paper reviewed the research advance to offer reference for clinical applications and development of new drug, in order to promote rational drug use.

关 键 词：消炎药 非甾类 注射剂 制剂开发 临床试验 

分 类 号：R971.1[医药卫生—药品]