Plasticity of language pathways in patients with low-grade glioma A diffusion tensor imaging study  

作　　者：Gang Zheng Xiaolei Chen Bainan Xu Jiashu Zhang Xueming Lv Jinjiang Li Fangye Li Shen Hu Ting Zhang Ye Li 

机构地区：[1]Department of Neurosurgery, Chinese PLA General Hospital [2]Chinese PLA Postgraduate Medical School

出　　处：《Neural Regeneration Research》2013年第7期647-654,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China, No. 31040039;the Natural Science Foundation of Beijing, No. 7102145;the Military Clinical High-Tech Foundation, No. 2010gxjso94

摘　　要：Knowledge of the plasticity of language pathways neurosurgeons to achieve maximum resection wh n patients with low-grade glioma is important for e preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.Knowledge of the plasticity of language pathways neurosurgeons to achieve maximum resection wh n patients with low-grade glioma is important for e preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.

关 键 词：neural regeneration neuroimaging low-grade glioma PLASTICITY language pathways dlllUSlOntensor imaging fractional anisotropy lateralization index ventral language pathway dorsallanguage pathway glioma grants-supported paper photographs-containing paper neuroregeneration 

分 类 号：R739.4[医药卫生—肿瘤]