米非司酮对人胎儿心肌组织超微结构的影响  

Effects of Mifepristone on ultrastructure of human fetal myocardial tissue

作　　者：王自能[1] 朱颖嫄[1] 卢凤昕[1] 

机构地区：[1]暨南大学医学院第一附属医院妇产科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》2000年第4期1-4,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国务院侨务办公室基金;广东省卫生厅科研基金 (A 19972 85 )资助项目

摘　　要：目的 :探讨米非司酮对人胎儿心肌组织超微结构的影响。方法 :将中孕期引产的病例分为米非司酮组与对照组 ,每组各 5例 ,胎龄为 18～ 2 1孕周。米非司酮组在引产前 6h服用 150mg米非司酮 ,然后行水囊引产术 ,对照组则只行水囊引产术。胎儿娩出后 ,取心肌组织进行样品制备以供透射电镜观察。结果 :与对照组相比 ,在米非司酮引产的胎心肌组织可见下列形态改变 :( 1)心肌细胞水肿 ,线粒体明显肿胀 ;( 2 )胞质内糖原颗粒缺如 ;( 3)部分心肌细胞肌丝呈棉絮样改变 ,横纹消失 ;( 4 )间质可见溢出红细胞及血小板及其它细胞碎片。结论 :米非司酮可造成胎心肌组织缺氧性损伤。因此 ,使用米非司酮于晚期引产可能给新生儿造成心脏功能损伤的后遗症。Aim: To investigate the influence of mifepristone on ultrastructure of human fetal myocardial tissue. Methods: 10 pregnant women (gestational duration ranged from 19 to 21 weeks) with indication for pregnancy termination were recuited and randomly divided into 2 groups. Mifepristone group ( n =5), 150 mg mifepristone per os was given six hours before labor was induced, control group ( n =5), labor induction was performed by extra-amniotic insertion of waterbag. Immediately after delivery of fetus, myocardial tissue was acquired and prepared for transmission electron microscopic examination. Results: In comparison with the control groups, the myocardial tissue of mifepristone group displayed the following morphological changes: 1. Muscle cells were edematous,mitochondria were markedly swollen. 2. Glycogen particles were completely depleted in cytoplasm. 3.In some muscle cells, myofilaments were flocky in appearance and showed no cross striations. 4.In interstitium, extravasal red cells, thrombocytes and cell debris were often seen. Conclusion: Mifepristone caused an hypoxic damage in fetal myocardial tissue. Therefore, using mifepristone in labor induction for full term pregnancy might leave a myocardial insufficiency for the new born infants. [

关 键 词：米非司酮 心肌组织 胎儿 超微结构 缺氧性损性 

分 类 号：R714.51[医药卫生—妇产科学]