血液循环和植物来源miRNA的研究进展  

The Advance in Research on Circulating and Plant-Drived miRNA

作　　者：杨中保[1] 彭军[1] 

机构地区：[1]中南大学药学院药理学系,湖南省长沙市410078

出　　处：《中国动脉硬化杂志》2013年第3期271-274,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(30971194)

摘　　要：miRNA是一类19～25个核苷酸大小的非编码RNA,参与了基因的转录与翻译的调节,广泛参与了哺乳动物体内肿瘤和心脑血管疾病等的发生、发展过程。最近研究表明,外周血液中存在miRNA,具有良好的稳定性。循环中某些miRNA水平变化与某些疾病的发生、发展和预后密切相关,可能是一种新的疾病生物标记物。植物来源的miRNA可以稳定地存在于动物的血液,并参与了机体多种靶蛋白的调控。检测血液中植物源性miRNA水平的变化,对于评估中药的疗效和阐明其作用机制具有重要意义。MiRNA are non-coding RNAs with 19～25 nucleotides in length, which play an important role in regulation of gene transcription and translation and greatly contribute to the development of tumor and cardiocerebral vascular diseases. Recently studies show that miRNAs stably exist in the peripheral blood. Changes of miRNA levels in the circulation are closely related to the occurrence, development and prognosis of multiple diseases. Therefore miRNAs may be a novel class of biomarkers for diseases. Plant-derived miRNAs can also stably exist in the blood and participate in the regulation of many target proteins of animals. It is of great significance to assess the efficacy of traditional Chinese medicine and to clarify the underlying mechanisms through examining the changes of plant-derived miRNA levels in the blood.

关 键 词：循环miRNA 植物来源miRNA 疾病标记物 中药机制 

分 类 号：R96[医药卫生—药理学]