黑升麻提取物治疗围绝经期骨质疏松患者的疗效  

Effect of cimicifuga racesoma on peri-menopausal osteoporosis patients

作　　者：刘颖[1] 陈中沛[2] 邓武权[1] 姜友昭[1] 吴绮楠[1] 陈兵[1] 王富华[1] 

机构地区：[1]第三军医大学第一附属医院内分泌科,重庆400038 [2]重庆市中医院内分泌科

出　　处：《中国老年学杂志》2013年第6期1241-1242,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(No.30670838)

摘　　要：目的观察黑升麻应用于围绝经期骨质疏松患者的疗效。方法将87例围绝经期骨质疏松患者随机分为两组,替勃龙治疗组在基础治疗上加用替勃龙,黑升麻治疗组在基础治疗上加用黑升麻治疗,两组均连续服药6个月,治疗前后检测骨密度(BMD),雌二醇和骨代谢指标:骨碱性磷酸酶(BALP)、Ⅰ型胶原C端肽(CTX)。结果经过6个月的治疗,在BMD、雌二醇和骨代谢指标的改善程度上,两组均较治疗前有明显改善,而两组间相比其差异无统计学意义(P<0.05)。结论替勃龙和黑升麻均能有效治疗围绝经期骨质疏松,在对围绝经期骨质疏松患者的BMD,雌二醇和骨代谢指标改善程度上,黑升麻治疗组不劣于替勃龙治疗组。Objective To investigate the treatment effect of Cimicifuga racemosa in peri-menopausal osteoporosis patients. Methods 87 patients of pefi-menopausal osteoporosis were randomly divided into two groups. Patients in tibolone treatment group were received basic treatment and tibolone treatment, in Cimicifuga racemosa treatment group were received basic and Cimicifuga racemosa treatment. Patients in two groups were treated for 6 months, and after treatment, bone mineral density（ BMD）, estradiol and bone metabolic markers： bone alkaline phosphatase （ BALP）, type I coliagen C end peptide （CTX） were detected. Results After 6 months of treatment, patients＇ BMD of each group, estradiol, BALP and CTX were significantly were improved （ P 〈 0. 05 ） , but there were no difference in BMD, estradiol, BALP and CTX between two groups after treatment （ P 〉 0. 05 ） . Conclusions Cimicifuga racemosa and Tibolone can effectively cure peri-menopausal osteoporosis.

关 键 词：黑升麻 围绝经期 骨质疏松 

分 类 号：R285[医药卫生—中药学]