阿托伐他汀联合辅酶Q10对心肌梗死后心力衰竭大鼠游离脂肪酸及三磷酸腺苷水平的影响  

Effect of atorvastatin and coenzyme Q10 on the contents of free fatty acid and ATP in heart failure rats after acute myocardial infarction

作　　者：赵东明[1] 杨萍[1] 杨杰[1] 魏群[2] 

机构地区：[1]吉林大学中日联谊医院心内科,吉林长春130033 [2]天津市第四中心医院心内科

出　　处：《中国老年学杂志》2013年第6期1296-1297,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(No.30770883)

摘　　要：目的探讨联合应用阿托伐他汀及辅酶Q10改善心衰大鼠能量代谢的作用机制。方法将大鼠左冠状动脉前降支结扎,存活的24只大鼠饲养6 w,随机分为4组:假手术组、模型组、阿托伐他汀组、阿托伐他汀+辅酶Q10组,每组6只,灌胃给药5 w后测定血清游离脂肪酸(FFA)及非梗死区心肌组织三磷酸腺苷(ATP)含量。结果联合应用辅酶Q10及阿托伐他汀组大鼠心肌组织中ATP的含量升高,血清FFA的含量降低(P<0.05)。结论联合应用辅酶Q10及阿托伐他汀可能通过纠正心衰时FFA及ATP的代谢紊乱,改善心衰时心肌重构过程中的能量代谢。Objective To investigate the metabolic remodeling effects of atorvastatin and coenzyme Q10 on experimental heart failure in rats after myocardial infarction（MI）.Methods The rat model of heart failure was established by left anterior descending coronary artery deligation.After 6 w,24 surviving rats were divided into sham,model,atorvastatin group and atorvastatin＋coenzyme groups at random,6 rats in each,and were treated with medicines by intragastric administration respectively.At 12 w,the level of serum free fatty acid（FFA） and the content of ATP in the noninfarcted area of the left ventricle were measured.Results Atorvastatin association with coenzyme Q10 increased the content of ATP,whereas decreased the level of FFA in serum（P0.05）.Conclusions Atorvastatin association with coenzyme Q10 has retrieve energy metabolism disturbance FFA and ATP to improve metabolic remodeling on heart failure after AMI in rats.

关 键 词：阿托伐他汀 辅酶Q10 心力衰竭 ATP FFA 

分 类 号：R541.6[医药卫生—心血管疾病]