白细胞介素1B基因多态性与慢性阻塞性肺疾病关系的荟萃分析  

Association between interleukin-lB polymorphisms and chronic obstructive pulmonary disease： a meta-analysis

作　　者：梅静静[1] 梁瀛[1] 沈宁[1] 贺蓓[1] 

机构地区：[1]北京大学第三医院呼吸科,100191

出　　处：《中华医学杂志》2013年第12期910-915,共6页National Medical Journal of China

基　　金：北京市自然科学基金（7112145）

摘　　要：目的评价白细胞介素1B（IL-1B）基因的-511C／T、-31T／C、＋3954C／T基因多态性与慢性阻塞性肺疾病发病（COPD）的相关性。方法全面检索PubMed、Embase、Ovid数据库、万方数据库及中国期刊全文数据库获取IL-1B基因多态性与COPD易感性的病例．对照研究，采用等位基因位点、显性遗传模型、隐性遗传模型、共显性遗传模型分别评价COPD发病的相对危险度，并通过人种分组、对各基因多态性进行亚组分析。运用荟萃分析方法综合评价IL-1B基因的-511C／T、-31T／C、＋3954C／T基因多态性与COPD的相关性。结果共有7篇病例．对照研究文献被纳入，荟萃分析结果显示-511C／T、-31T／C、＋3954C／T基因多态性与COPD均无显著相关性，但以人种分组的亚组分析显示：-511C／T的T等位基因在高加索人中与COPD显著相关（OR=1．76，95％CI为1．22-2．54，P=0．002），但在亚洲人中无相关性（OR=0．94，95％CI为0．64～1．38，P=0．736）。-31T／C的C等位基因在高加索人中与COPD显著相关（OR=0．62，95％CI为0．40—0．97，P=0．035），但在亚洲人中无相关性（OR=1．06，95％CI为0．89-1．26，P=0．533）。结论IL．1B基因多态性与COPD的易感性有人种差异；在高加索人中，IL-1B-511C／T的T等位基因与COPD发病风险呈正相关，IL-1B-31T／C的C等位基因与COPD发病风险呈负相关。Objective To explore the association between the - 511 C/T, - 31T/C and ＋ 3954C/ T polymorphisms of interleukin-1 B （IL-1 B） gene and chronic obstructive pulmonary disease （COPD） using the method of recta-analysis. Methods Comprehensive searches were performed of PubMed, Embase, Ovid, Wanfang and Chinese journal full-text database to retrieve the related case-control studies. The pooled odds ratios were performed respectively for allele comparison, additive genetic model, dominant genetic model and recessive genetic model and subgroup analysis was also performed by ethnicity. Results Seven case-control studies were included for meta-analysis. Pooled analysis showed that neither -511C/T, -31T/C nor ＋ 3954 C/T polymorphisms increased the susceptibility to COPD. In the subgroup analysis by ethnicity, significant risks were found in the Caucasian population for - 511 C/T T allele （ OR = 1.76, 95% CI 1.22 -2. 54, P = 0. 002）, but not in the Asian population（ OR = 0. 94, 95% CI 0. 64 - 1.38, P = 0. 736）. Significant risks were also found in the Caucasian population for -31T/C C allele （OR = 0. 62, 95 % CI 0. 40 - 0. 97, P =0. 035 ） , but not in the Asian population （ OR = 1.06, 95 % CI 0. 89 - 1.26, P = 0. 533）. Conclusions IL-1B polymorphisms may play a role in the susceptibility of COPD in an ethnicity- specific manner. In the Caucasian population, the risk of COPD was associated positively with the IL-1B - 511C/T T allele and negatively with the IL-1B - 31T/C C allele.

关 键 词：白细胞介素1 多态性 单核苷酸 肺疾病 慢性阻塞性 Meta分析 

分 类 号：R563.9[医药卫生—呼吸系统]