MicroRNA与哺乳动物的性腺发育  

MicroRNA and Gonadal Development in Mammals

作　　者：向浩[1,2] 张晓东[1,2] 凌英会[1,2] 丁建平[1,2] 章孝荣[1,2] 

机构地区：[1]安徽农业大学动物科技学院,安徽合肥230036 [2]安徽地方畜禽遗传资源保护与生物育种省级实验室,安徽合肥230036

出　　处：《家畜生态学报》2013年第1期73-77,共5页Journal of Domestic Animal Ecology

基　　金：国家高技术研究发展计划(863)计划项目(2011AA100307);安徽省科技计划项目(11010302108)

摘　　要：MicroRNAs(miRNAs)是一类长约21～24nt的非编码RNA,他们通过剪切靶基因的转录产物或者抑制转录产物的翻译从而起到转录后调控靶基因表达的作用。miRNA能调控卵巢和睾丸发育,还能促进卵母细胞的成熟和精子的分化,与哺乳动物性腺发育有着极其紧密的关系。论文对miRNA的生物合成、作用方式及其在哺乳动物性腺发育中的调控作用作一综述。MicroRNAs（miRNAs）, a class of noncoding RNA of approximately 21-24 nucleotides in length, play a role in post-transcriptional regulation of target gene expression by cutting the transcript of target genes or inhibit the translation of the transcript. It was found that miRNA can regulate the develop- ment of ovarian and testicular, and promote the maturation of oocytes and the differentiation of sperm, which has an extremely close relationship with gonadal development of mammals. This paper reviewed miRNAs＂ biogenesis, mechanism of action and its regulation in mammals gonadal development.

关 键 词：MICRORNA 哺乳动物 性腺 发育 

分 类 号：S811.6[农业科学—畜牧学]