吸烟量与CHRNA7基因多态性对高血糖症的联合作用  

Joint effects of smoking quantity and CHRNA7 polymorphisms on hyperglycemia

作　　者：周珊宇[1] 吴晓瑛[1] 刘涛[1] 谢传波[1] 王辉[1] 邱泉[1] 丁鹏[1] 陈维清[1] 

机构地区：[1]中山大学公共卫生学院医学统计与流行病学系,广东广州510080

出　　处：《中华疾病控制杂志》2013年第3期190-194,共5页Chinese Journal of Disease Control & Prevention

基　　金：广州市医药卫生科技重大项目(2005-zda-001)

摘　　要：目的探讨吸烟量与CHRNA7基因多态性对高血糖症的联合作用。方法调查909名男性吸烟者的社会人口学特征及吸烟行为等信息,并采集静脉血检测空腹血糖及CHRNA7上SNP位点rs2337980的多态性。在控制年龄、职业和糖尿病家族史后,应用多因素Logistic回归模型,分析吸烟量和CHRNA7基因多态性对高血糖症的联合作用。结果 909名男性吸烟者中,有166人(18.3%)为高血糖症,743人(81.7%)为正常血糖者。在控制年龄、职业和糖尿病家族史后,吸烟量>15支/天的男性比吸烟量为1～15支/天者患高血糖症的风险增高(OR=1.51,95%CI:1.06～2.14),携带变异基因型(CC+CT)的个体较携带rs2337980野生基因型(CC)患高血糖症的危险性增高(OR=1.74,95%CI:1.22～2.48)。在控制年龄、职业、糖尿病家族史和吸烟年数后,进一步根据CHRNA7上SNP位点rs2337980的多态性和每日吸烟量进行分层分析,以携带野生基因型(CC)且吸烟量1～15支/天者为参照组,携带野生基因型(CC)且吸烟量>15支/天者、携带变异基因型(CT+TT)且每日吸烟1～15支/天者和携带变异基因型(CT+TT)且吸烟者量>15支/天者患高血糖症的危险性呈递增趋势,OR值分别为1.81(95%CI:1.07～3.07)、2.06(95%CI:1.26～3.38)和2.52(95%CI:1.52～4.17)。但未发现每日吸烟量和rs2337980多态性对高血糖症有交互作用。结论每日吸烟量与CHRNA7基因多态性对高血糖症有联合作用。Objective To explore the joint effects of smoking quantity and c^7 nicotinic acetylcholine receptor sub- unit gene （CHRNA7） on hyperglycemia. Methods A total of 909 male smokers were interviewed with a structured ques- tionnaire about socio-demographic status and smoking behavior. Venous blood samples were collected to measure fasting se- rum glucose and a single nucleotide polymorphisms （SNPs） rs2337980 in CHRNA7. A series of multivariate Logistic re- gression models were performed to assess the join effects of smoking quantity and CHRNA7 gene polymorphisms on hyper- glycemia with adjustment for age, occupation and family history of diabetes. Results There were 166（ 18.3% ） hypergly- cemia and 743 （81.7%） normoglycemia individuals in 909 male smokers. Multivariate Logistic regression analysis indica- ted that individuals smoking 〉 15 cigarettes per day significantly increased the risk of hyperglycemia （ OR = 1.51, 95% CI： 1.06-2. 14） than those smoking 1-15 cigarettes per day after adjusting the potential confounders. In addition, compared to those with wide type （CC） of rs2337980, individuals with variant type （ CT ＋ TT） of rs2337980 had an increased risk of hyperglycemia （OR = 1.74,95% CI： 1.22-2. 48）. A further stratified analysis by smoking quantity and rs2337980 geno- types indicated that compared with individuals smoking 1-15 cigarettes per day and carrying wild type of rs2337980, the in- creased risk of hyperglycemia was observed in ones smoking 〉 15 cigarettes per day and carrying wild type （ OR = 1.81, 95% CI： 1.07-3.07）, ones smoking 1-15 cigarettes per day and carrying variant type （ OR = 2.06, 95% CI： 1.26-3.38 ） and ones smoking 〉 15 cigarettes per day and carrying variant type （ OR = 2. 52, 95% CI： 1.52-4. 17 ） after adjusting for the potential confounders. But, it was not found that smoking quantity and rs2337980 polymorphisms interactively affected on hyperglycemia. Conclusions These findings suggested that smoking quantity and CHRNA7

关 键 词：吸烟 基因 高血糖症 

分 类 号：R587.9[医药卫生—内分泌]