补阳还五汤与腰交感神经节切除对坐骨神经损伤模型大鼠足部皮肤温度的影响  

Comparison of effect of Buyanghuanwu decoction and lumbar sympathetic ganglionectomy on the rats foot skin temperature

作　　者：刘青龙 秦振龙[2] 王绣伯[3] 刘丽 韩冬梅 陈树山 

机构地区：[1]河北省唐山市中医医院外科,河北唐山063000 [2]北京中医药大学附属医院东方医院麻醉科,北京100078 [3]中国航天科技集团公司第五研究院502研究所第5研究院门诊部内科,北京100190

出　　处：《河北中医》2013年第1期110-111,共2页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2012年度中医药类科研计划课题(编号:2012145)

摘　　要：目的探讨补阳还五汤口服加药浴与腰交感神经节切除(LSGT)对大鼠造模足部皮肤温度的影响。方法将60只坐骨神经损伤模型SD大鼠随机分为2组。实验组30只予补阳还五汤口服及药浴;对照组30只行第2～5腰椎左侧腰交感神经节切除术。观察2组第6 d及2、4、6周后左后足部皮肤温度的差别。结果实验组第6 d及2、4、6周后左后足部皮肤温度均高于对照组(P<0.05)。结论补阳还五汤口服加药浴比LSGT对大鼠足部皮肤温度更有提高作用,可以使血液供应量得到明显的提高。Objective To investigate the effect of oral administration and medicine bath of Buyanghuanwu decoction and lumbar sympathetic ganglionectomy on the rats foot skin temperature. Methods 60 Sprague Dawley rats whose left sympathectic ganglion were exposed were divided into two groups. The rats in control group received sympathetic ganglionectomy （LSGT） while those in the experimental group take oral administration and medicine bath of Buyanghuanwu decoction. Their foot temperature were studied before and after injury. Results Their foot temperature in experimental group was significantly higher than those in control group （ P 〈 0.05 ） after LSGT therapy for 2, 4, 6 weeks respectively. The foot temperature in control group was （ 31. 12 ± 0. 09） ℃ while （ 31.93± 0.14） ℃ in experimental group at 2 weeks, （31. 97 ± 0.10）℃ in experimental group, while （31.11 ± 0.11 ）℃ in control group at 4 weeks. （ 31.97± 0.50 ）℃ in control group, （ 31.09 ± 0.12 ） ℃ in experimental group at 6 weeks. Conclusion The effect of oral administration and medicine bath of Buyanghuanwu decoction is better than lumbar sympathetic ganglionectomy on the raise of the rats foot skin temperature, it can significantly improve the blood supply.

关 键 词：大鼠 Sprague-Dawley 补阳还五汤 交感神经切除术 皮肤温度 

分 类 号：R332[医药卫生—人体生理学] R289[医药卫生—基础医学]